Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19

Marcela Karey Tello-Ruiz, Christine Curley, Terrye DelMonte, Cosmas Giallourakis, Andrew Kirby, Kathryn Miller, Gary Wild, Albert Cohen, Diane Langelier, Anna Latiano, Neils Wedemeyer, Eric Lander, Stefan Schreiber, Vito Annese, Mark J. Daly, John D. Rioux

Research output: Contribution to journalArticle

Abstract

Evidence from four independent linkage studies and two meta-analyses of genome-wide data support the existence of a locus conferring susceptibility to inflammatory bowel diseases (IBD) in chromosomal region 19p. Identification of a susceptibility allele in this ∼28.5 Mb region with over 600 genes is a formidable task. To tackle this problem, we undertook two approaches: (1) haplotype-based candidate-gene screen, and (2) evaluation of previously reported associations. For the former, we selected genes with potential implication in IBD pathogenesis based on published functional and expression data, typed SNPs, constructed haplotypes, screened for association in 180 IBD trios, and followed up preliminary associations in 343 IBD patients and 207 control individuals. Overall, we analyzed 465 SNPs, and 260 haplotypes distributed across 56 candidate genes. We found suggestive evidence of association (nominal P

Original languageEnglish
Pages (from-to)780-790
Number of pages11
JournalEuropean Journal of Human Genetics
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Candidate-gene association
  • IBD6
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Genetics(clinical)

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    Tello-Ruiz, M. K., Curley, C., DelMonte, T., Giallourakis, C., Kirby, A., Miller, K., Wild, G., Cohen, A., Langelier, D., Latiano, A., Wedemeyer, N., Lander, E., Schreiber, S., Annese, V., Daly, M. J., & Rioux, J. D. (2006). Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. European Journal of Human Genetics, 14(6), 780-790. https://doi.org/10.1038/sj.ejhg.5201612