Abstract
Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis of obstetric complications, as fetal loss and pregnancy-related hypertensive disorders is still partly unexplained. Recently, a common haplotype (M2) within the annexin A5 (ANXA5) gene has been described as a risk factor in recurrent fetal losses (RFL). It has been demonstrated to reduce the promoter activity of the ANXA5 promoter in luciferase reporter assays. Aim of this study was to investigate the prevalence of M2 haplotype in three different settings of women with previous obstetric complications: RFL, intra-uterine fetal death (IUFD) and pregnancy-related hypertension (gestational hypertension [GH] and pre-eclampsia [PE]). One hundred three patients with previous RFL, 54 with IUFD, 158 with hypertensive disease (67 GH, 91 PE) were investigated. As controls, 195 women from the same ethnic background with uneventful pregnancies were enrolled. Logistic regression, correcting for age, gravidity and parity showed that the ANXA5 haplotype is significantly and independently associated with the occurrence of RFL (3.1; 95%CI: 1.1-9.5; p=0.047) and pregnancy-related hypertensive disorders (2.1; 95%CI: 1.2-3.5; p=0.008). The M2 haplotype might be a new and relevant risk factor for obstetric complications.
| Original language | English |
|---|---|
| Pages (from-to) | 309-313 |
| Number of pages | 5 |
| Journal | Thrombosis and Haemostasis |
| Volume | 102 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2009 |
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Keywords
- Annexins
- Polymorphism
- Pregnancy
- Risk factors
ASJC Scopus subject areas
- Hematology
Cite this
Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications. / Tiscia, Giovanni; Colaizzo, Donatella; Chinni, Elena; Pisanelli, Daniela; Sciannamè, Natale; Favuzzi, Giovanni; Margaglione, Maurizio; Grandone, Elvira.
In: Thrombosis and Haemostasis, Vol. 102, No. 2, 08.2009, p. 309-313.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications
AU - Tiscia, Giovanni
AU - Colaizzo, Donatella
AU - Chinni, Elena
AU - Pisanelli, Daniela
AU - Sciannamè, Natale
AU - Favuzzi, Giovanni
AU - Margaglione, Maurizio
AU - Grandone, Elvira
PY - 2009/8
Y1 - 2009/8
N2 - Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis of obstetric complications, as fetal loss and pregnancy-related hypertensive disorders is still partly unexplained. Recently, a common haplotype (M2) within the annexin A5 (ANXA5) gene has been described as a risk factor in recurrent fetal losses (RFL). It has been demonstrated to reduce the promoter activity of the ANXA5 promoter in luciferase reporter assays. Aim of this study was to investigate the prevalence of M2 haplotype in three different settings of women with previous obstetric complications: RFL, intra-uterine fetal death (IUFD) and pregnancy-related hypertension (gestational hypertension [GH] and pre-eclampsia [PE]). One hundred three patients with previous RFL, 54 with IUFD, 158 with hypertensive disease (67 GH, 91 PE) were investigated. As controls, 195 women from the same ethnic background with uneventful pregnancies were enrolled. Logistic regression, correcting for age, gravidity and parity showed that the ANXA5 haplotype is significantly and independently associated with the occurrence of RFL (3.1; 95%CI: 1.1-9.5; p=0.047) and pregnancy-related hypertensive disorders (2.1; 95%CI: 1.2-3.5; p=0.008). The M2 haplotype might be a new and relevant risk factor for obstetric complications.
AB - Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis of obstetric complications, as fetal loss and pregnancy-related hypertensive disorders is still partly unexplained. Recently, a common haplotype (M2) within the annexin A5 (ANXA5) gene has been described as a risk factor in recurrent fetal losses (RFL). It has been demonstrated to reduce the promoter activity of the ANXA5 promoter in luciferase reporter assays. Aim of this study was to investigate the prevalence of M2 haplotype in three different settings of women with previous obstetric complications: RFL, intra-uterine fetal death (IUFD) and pregnancy-related hypertension (gestational hypertension [GH] and pre-eclampsia [PE]). One hundred three patients with previous RFL, 54 with IUFD, 158 with hypertensive disease (67 GH, 91 PE) were investigated. As controls, 195 women from the same ethnic background with uneventful pregnancies were enrolled. Logistic regression, correcting for age, gravidity and parity showed that the ANXA5 haplotype is significantly and independently associated with the occurrence of RFL (3.1; 95%CI: 1.1-9.5; p=0.047) and pregnancy-related hypertensive disorders (2.1; 95%CI: 1.2-3.5; p=0.008). The M2 haplotype might be a new and relevant risk factor for obstetric complications.
KW - Annexins
KW - Polymorphism
KW - Pregnancy
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=70350442918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350442918&partnerID=8YFLogxK
U2 - 10.1160/TH09-02-0123
DO - 10.1160/TH09-02-0123
M3 - Article
C2 - 19652881
AN - SCOPUS:70350442918
VL - 102
SP - 309
EP - 313
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 2
ER -