Haptoglobin phenotype and epithelial ovarian cancer

Vincenzo Dario Mandato, Elena Magnani, Martino Abrate, Bruno Casali, Davide Nicoli, Enrico Farnetti, Debora Formisano, Debora Pirillo, Gino Ciarlini, Pierandrea De Iaco, Isabella Strada, Claudio Zamagni, Giovanni Battista La Sala

Research output: Contribution to journalArticle

Abstract

Background: Haptoglobin (H) is a glycoprotein that regulates the immune response. Serum haptoglobin levels are significantly higher in patients with advanced epithelial ovarian cancer (EOC) with poor survival. Different isoforms of haptoglobin have been found in the serum of patients with EOC. We studied the genetic susceptibility and outcome of patients with EOC correlated to H phenotypes. Materials and Methods: Analyses of the H phenotypes were performed on sera from patients stored at -70°C. A modified method based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of sera was used, followed by western blotting. Results: Seventy-nine consecutive patients with EOC and 63 healthy women were enrolled. Their mean (±S.D.) age was 58.9±12.46 years. Overall survival was 66 months (95% confidence interval=37.7-94.2). Similar distribution of haptoglobin phenotypes was observed in EOC and in healthy women. No significant correlation was found between haptoglobin phenotype, overall survival and time-to- progression. Fewer G3 tumors were found in patients with H2-2 compared with those with H1-2 (84.2% and 90.6%, respectively, p

Original languageEnglish
Pages (from-to)4353-4358
Number of pages6
JournalAnticancer Research
Volume32
Issue number10
Publication statusPublished - Oct 2012

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Keywords

  • Cancer biomarkers
  • Epithelial ovarian cancer
  • Haptoglobin phenotypes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mandato, V. D., Magnani, E., Abrate, M., Casali, B., Nicoli, D., Farnetti, E., Formisano, D., Pirillo, D., Ciarlini, G., De Iaco, P., Strada, I., Zamagni, C., & La Sala, G. B. (2012). Haptoglobin phenotype and epithelial ovarian cancer. Anticancer Research, 32(10), 4353-4358.