Hashimoto's thyroiditis: Influence of adherent cells on T lymphocytes colony growth

S. Ferrini, M. Bagnasco, D. Ramarli

Research output: Contribution to journalArticle

Abstract

Human T lymphocytes, after phytohaemagglutinin (PHA) stimulation, are able to develop colonies in semisolid agar culture. Adherent cells (AC) or their conditioned media are necessary in order to produce a proliferative response of T cells in this experimental model. Previous investigation using this method demonstrated a defective function of AC in primary biliary cirrhosis, an autoimmune liver disease. Recent reports suggested a possible pathogenetic role of monocytes in Hashimoto's disease (HD). This aspect of AC function was studied in 6 patients and in 6 healthy controls. The number of colonies developed by T lymphocytes in HD patients did not differ from that of controls; in addition the depletion of AC in both groups resulted in a sharp decrease in colony development, which could be restored by AC from normal or HD subjects. These experiments indicate the normal capability of HD - AC to react with T lymphocytes in the proliferative response to PHA, but does not exclude their possible pathogenetic role in this disease.

Original languageEnglish
Pages (from-to)1085-1086
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number12
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Ferrini, S., Bagnasco, M., & Ramarli, D. (1981). Hashimoto's thyroiditis: Influence of adherent cells on T lymphocytes colony growth. IRCS Medical Science, 9(12), 1085-1086.