Hashimoto's thyroiditis

Influence of adherent cells on T lymphocytes colony growth

S. Ferrini, M. Bagnasco, D. Ramarli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human T lymphocytes, after phytohaemagglutinin (PHA) stimulation, are able to develop colonies in semisolid agar culture. Adherent cells (AC) or their conditioned media are necessary in order to produce a proliferative response of T cells in this experimental model. Previous investigation using this method demonstrated a defective function of AC in primary biliary cirrhosis, an autoimmune liver disease. Recent reports suggested a possible pathogenetic role of monocytes in Hashimoto's disease (HD). This aspect of AC function was studied in 6 patients and in 6 healthy controls. The number of colonies developed by T lymphocytes in HD patients did not differ from that of controls; in addition the depletion of AC in both groups resulted in a sharp decrease in colony development, which could be restored by AC from normal or HD subjects. These experiments indicate the normal capability of HD - AC to react with T lymphocytes in the proliferative response to PHA, but does not exclude their possible pathogenetic role in this disease.

Original languageEnglish
Pages (from-to)1085-1086
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number12
Publication statusPublished - 1981

Fingerprint

Hashimoto Disease
T-cells
T-Lymphocytes
Growth
Phytohemagglutinins
Biliary Liver Cirrhosis
Conditioned Culture Medium
Liver
Autoimmune Diseases
Agar
Liver Diseases
Monocytes
Theoretical Models
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ferrini, S., Bagnasco, M., & Ramarli, D. (1981). Hashimoto's thyroiditis: Influence of adherent cells on T lymphocytes colony growth. IRCS Medical Science, 9(12), 1085-1086.

Hashimoto's thyroiditis : Influence of adherent cells on T lymphocytes colony growth. / Ferrini, S.; Bagnasco, M.; Ramarli, D.

In: IRCS Medical Science, Vol. 9, No. 12, 1981, p. 1085-1086.

Research output: Contribution to journalArticle

Ferrini, S, Bagnasco, M & Ramarli, D 1981, 'Hashimoto's thyroiditis: Influence of adherent cells on T lymphocytes colony growth', IRCS Medical Science, vol. 9, no. 12, pp. 1085-1086.
Ferrini, S. ; Bagnasco, M. ; Ramarli, D. / Hashimoto's thyroiditis : Influence of adherent cells on T lymphocytes colony growth. In: IRCS Medical Science. 1981 ; Vol. 9, No. 12. pp. 1085-1086.
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