Have antipsychotics a different speed of action in the acute treatment of mania? A single-blind comparative study

Massimiliano Buoli, Cecilia Maria Esposito, Marco Godio, Alice Caldiroli, Marta Serati, A. Carlo Altamura

Research output: Contribution to journalArticlepeer-review

Abstract

Available antipsychotics show different efficacy on manic symptoms of bipolar patients, but few studies have investigated the speed of action of the various compounds. For this reason, purpose of the present paper was to compare antipsychotic mono-therapies in terms of speed of action in a sample of manic bipolar patients. In total, 155 bipolar patients, treated with antipsychotic mono-therapy and followed-up in Inpatient Psychiatry Clinic of University of Milan, were included in this single-blind comparative study. Clinical response was defined as a reduction of Young Mania Rating Scale (YMRS) scores ⩾50%, while remission as a YMRS score <10. After 4 days patients who had been treated with asenapine, were more likely to have achieved a clinical response than those in treatment with haloperidol (p = 0.001). After 7 days, a more frequent clinical response was achieved by patients treated with asenapine than those who had been treated with haloperidol (p < 0.001) or olanzapine (p = 0.047). Asenapine appears to be faster in determining treatment response in manic patients compared with haloperidol and less markedly with olanzapine.

Original languageEnglish
Pages (from-to)1537-1543
Number of pages7
JournalJournal of Psychopharmacology
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Bipolar disorder
  • drugs for psychosis
  • mania
  • speed of action

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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