HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects from the ICONA Italian Cohort of HIV-Infected Patients

Vincenzo Malagnino, Carlotta Cerva, Antonella Cingolani, Francesca Ceccherini-Silberstein, Alessandra Vergori, Gianluca Cuomo, Carlo Federico Perno, Massimo Puoti, Antonella D'Arminio Monforte, Alessandro Cozzi-Lepri, Massimo Andreoni, Loredana Sarmati

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). Methods: All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. Results: Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)-and HCV+/HBcAb+/HBsAg-or HBsAg+/HBcAb+/HCV-had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P <. 0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg-patients (HR, 7.2; 95% CI, 3 8-13.64). Conclusions: HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg-subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalOpen Forum Infectious Diseases
Volume8
Issue number1
DOIs
Publication statusE-pub ahead of print - Nov 18 2020

Keywords

  • anti-HBc
  • HBV
  • HIV/HBV coinfection
  • liver fibrosis
  • OBI

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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