HBsAg research by monoclonal radioimmunoassay in different groups of patients with hepatitis

G. Marinucci, C. Di Giacomo, F. Costa, G. Iannicelli, N. Orchi, V. Stimilli, G. M. De Sanctis, M. F. Magliocca, V. Vullo, L. V. Chircu

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Abstract

Polyclonal and monoclonal radioimmunoassay for HBsAg were performed in 58 subjects with acute or chronic NANB hepatitis (group A), in 7 with chronic non-B hepatitis (group B), in 7 with acute hepatitis due to HAV, CMV, or EBV (group C), in 2 subjects non-responders to HBV vaccine (group D), and in 20 subjects with acute or chronic HBV infection (group E). In group A, all patients were HBs negative by both methods, but 3 DA who were found positive only by M-RIA. Patients of group B, C, and D were HBs negative by both techniques. In group E HBs was evidenced in 5 patients by M-RIA whereas the research by polyclonal RIA was negative. The research of HBs by M-RIA is a useful technique being more sensitive than the polyclonal assay.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Volume24
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Marinucci, G., Di Giacomo, C., Costa, F., Iannicelli, G., Orchi, N., Stimilli, V., De Sanctis, G. M., Magliocca, M. F., Vullo, V., & Chircu, L. V. (1988). HBsAg research by monoclonal radioimmunoassay in different groups of patients with hepatitis. Annali dell'Istituto Superiore di Sanita, 24(2), 313-318.