HBV-DNA-related hepatocellular carcinoma occurring in childhood report of three cases

R. Giacchino, C. Navone, F. Facco, G. Giambartolomei, P. Pontisso, F. Callea

Research output: Contribution to journalArticlepeer-review


In a series of 325 HBV chronically infected children observed over an 18-year period, three developed HCC. These three children were born in southern Italy, a region characterized by a high endemic HBV infection rate; each had been infected perinatally, developed an acute hepatitis, and became a chronic carrier. Two of the three with cirrhosis were HBsAg positive at the time their HCC was detected. The remaining case had seroconverted to HBsAb but HBV-DNA integration could be demonstrated in the absence of cirrhosis; moreover HBV antigens were not expressed in the tissue of this case. The interval between HBV infection and HCC appearance in these three cases ranged from six to 11 years. A similarity between these three Italian cases and the majority of HCC, arising in chronically infected children in the Far East is noted.

Original languageEnglish
Pages (from-to)1143-1146
Number of pages4
JournalDigestive Diseases and Sciences
Issue number8
Publication statusPublished - Aug 1991


  • chronic hepatitis
  • hepatocellular carcinoma
  • viral DNA integration

ASJC Scopus subject areas

  • Gastroenterology

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