HBV-DNA-related hepatocellular carcinoma occurring in childhood report of three cases

R. Giacchino, C. Navone, F. Facco, G. Giambartolomei, P. Pontisso, F. Callea

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In a series of 325 HBV chronically infected children observed over an 18-year period, three developed HCC. These three children were born in southern Italy, a region characterized by a high endemic HBV infection rate; each had been infected perinatally, developed an acute hepatitis, and became a chronic carrier. Two of the three with cirrhosis were HBsAg positive at the time their HCC was detected. The remaining case had seroconverted to HBsAb but HBV-DNA integration could be demonstrated in the absence of cirrhosis; moreover HBV antigens were not expressed in the tissue of this case. The interval between HBV infection and HCC appearance in these three cases ranged from six to 11 years. A similarity between these three Italian cases and the majority of HCC, arising in chronically infected children in the Far East is noted.

Original languageEnglish
Pages (from-to)1143-1146
Number of pages4
JournalDigestive Diseases and Sciences
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 1991

Fingerprint

Hepatocellular Carcinoma
DNA
Fibrosis
Far East
Hepatitis B Surface Antigens
Infection
Italy
Hepatitis
Antigens

Keywords

  • chronic hepatitis
  • HBV DNA
  • hepatocellular carcinoma
  • viral DNA integration

ASJC Scopus subject areas

  • Gastroenterology

Cite this

HBV-DNA-related hepatocellular carcinoma occurring in childhood report of three cases. / Giacchino, R.; Navone, C.; Facco, F.; Giambartolomei, G.; Pontisso, P.; Callea, F.

In: Digestive Diseases and Sciences, Vol. 36, No. 8, 08.1991, p. 1143-1146.

Research output: Contribution to journalArticle

Giacchino, R, Navone, C, Facco, F, Giambartolomei, G, Pontisso, P & Callea, F 1991, 'HBV-DNA-related hepatocellular carcinoma occurring in childhood report of three cases', Digestive Diseases and Sciences, vol. 36, no. 8, pp. 1143-1146. https://doi.org/10.1007/BF01297462
Giacchino, R. ; Navone, C. ; Facco, F. ; Giambartolomei, G. ; Pontisso, P. ; Callea, F. / HBV-DNA-related hepatocellular carcinoma occurring in childhood report of three cases. In: Digestive Diseases and Sciences. 1991 ; Vol. 36, No. 8. pp. 1143-1146.
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