HBV infection in Italian family groups.

L. V. Chircu, G. Marinucci, C. Masala, C. Di Giacomo, D. Morganti, A. Amendolea, G. Sonego, A. M. Cilli, G. Settembre, G. Iannicelli

Research output: Contribution to journalArticlepeer-review


Intrafamilial spread of HBV infection was evaluated in 85 Italian family groups. Secondary infected cases were observed in 43% of these families, of which 73% showed clusters of HBs positive members, with a prevalence among the family members (children-siblings) of the mother/wife index cases, and no strict relation to their "e" system. The presence of the delta agent in the index case was correlated to a higher percentage of secondary HBs-positive cases, but the intrafamilial spread of delta agent was a rare event. A similar higher incidence of HBV markers was observed among the relatives of the index cases positive for auto-antibodies. The evidence presented suggests the importance of genetic factors in the acquisition and clearance of HBV and delta infections.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology


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