Hepatocellular carcinoma (HCC) ranks among the most common cancers worldwide, representing the sixth most common one and the third cause of cancer-related death, and accounts for 7 % of all cancers . HCC represents more than 90 % of primary liver cancers and is a major global health problem. Over the last three decades, the age-adjusted incidence of liver cancer has risen to 4.6 per 100,000 individuals. The incidence of HCC will likely continue to rise as the hepatitis C epidemic reaches maturity and nonalcoholic steatohepatitis becomes more prevalent. The incidence of HCC increases progressively with advancing age in all populations, reaching a peak at 70 years .
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