HCC, diet, and metabolic factors

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hepatocellular carcinoma is the most common primary liver malignancy and is an international public health concern, constituting one of the most deadly cancers worldwide. Infection with hepatitis B virus and hepatitis C virus is a major risk factor for HCC in developed countries. Emerging evidence indicates that there are other important lifestyle factors that contribute to the international burden of HCC, such as alcohol consumption, diabetes, obesity, and the intake of aflotoxin-contaminated food. Obesity and diabetes are also likely to be risk factors for HCC, the most frequent subtype of liver cancer. The chief pathway by which obesity increases risk involves the association between obesity and nonalcoholic fatty liver disease (NAFLD). Coffee consumption has been studied extensively and appears to have a favorable effect on the prevention of liver diseases, including HCC. One hypothesis suggests that coffee intake lowers serum levels of gamma-glutamyltransferase (GGT), which is associated with a lower incidence of HCC. It is estimated that more than 80% of HCC cases are attributable to four principal causes that are avoidable. It is difficult to make dietary recommendations, because it is unknown whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma. A diet rich that is in polyunsaturated fatty acids and, possibly, B-carotene could reduce the risk of HCC, and high dietary GL is associated with an increased risk independently of cirrhosis or diabetes.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalHepatitis Monthly
Volume11
Issue number3
Publication statusPublished - Mar 2011

Fingerprint

Obesity
Diet
Coffee
Hepatocellular Carcinoma
gamma-Glutamyltransferase
Carotenoids
Liver Neoplasms
Unsaturated Fatty Acids
Developed Countries
Hepatitis B virus
Alcohol Drinking
Hepacivirus
Life Style
Liver Diseases
Neoplasms
Fibrosis
Public Health
Antioxidants
Food
Liver

Keywords

  • Alcohol
  • Coffee
  • Diabetes mellitus
  • Diet
  • Hepatocellular carcinoma
  • Obesity

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

HCC, diet, and metabolic factors. / Montella, Maurizio; Crispo, Anna; Giudice, Aldo.

In: Hepatitis Monthly, Vol. 11, No. 3, 03.2011, p. 159-162.

Research output: Contribution to journalArticle

@article{d13a5775d101450080f3885e783b0ddd,
title = "HCC, diet, and metabolic factors",
abstract = "Hepatocellular carcinoma is the most common primary liver malignancy and is an international public health concern, constituting one of the most deadly cancers worldwide. Infection with hepatitis B virus and hepatitis C virus is a major risk factor for HCC in developed countries. Emerging evidence indicates that there are other important lifestyle factors that contribute to the international burden of HCC, such as alcohol consumption, diabetes, obesity, and the intake of aflotoxin-contaminated food. Obesity and diabetes are also likely to be risk factors for HCC, the most frequent subtype of liver cancer. The chief pathway by which obesity increases risk involves the association between obesity and nonalcoholic fatty liver disease (NAFLD). Coffee consumption has been studied extensively and appears to have a favorable effect on the prevention of liver diseases, including HCC. One hypothesis suggests that coffee intake lowers serum levels of gamma-glutamyltransferase (GGT), which is associated with a lower incidence of HCC. It is estimated that more than 80{\%} of HCC cases are attributable to four principal causes that are avoidable. It is difficult to make dietary recommendations, because it is unknown whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma. A diet rich that is in polyunsaturated fatty acids and, possibly, B-carotene could reduce the risk of HCC, and high dietary GL is associated with an increased risk independently of cirrhosis or diabetes.",
keywords = "Alcohol, Coffee, Diabetes mellitus, Diet, Hepatocellular carcinoma, Obesity",
author = "Maurizio Montella and Anna Crispo and Aldo Giudice",
year = "2011",
month = "3",
language = "English",
volume = "11",
pages = "159--162",
journal = "Hepatitis Monthly",
issn = "1735-143X",
publisher = "Kowsar Publishing Company",
number = "3",

}

TY - JOUR

T1 - HCC, diet, and metabolic factors

AU - Montella, Maurizio

AU - Crispo, Anna

AU - Giudice, Aldo

PY - 2011/3

Y1 - 2011/3

N2 - Hepatocellular carcinoma is the most common primary liver malignancy and is an international public health concern, constituting one of the most deadly cancers worldwide. Infection with hepatitis B virus and hepatitis C virus is a major risk factor for HCC in developed countries. Emerging evidence indicates that there are other important lifestyle factors that contribute to the international burden of HCC, such as alcohol consumption, diabetes, obesity, and the intake of aflotoxin-contaminated food. Obesity and diabetes are also likely to be risk factors for HCC, the most frequent subtype of liver cancer. The chief pathway by which obesity increases risk involves the association between obesity and nonalcoholic fatty liver disease (NAFLD). Coffee consumption has been studied extensively and appears to have a favorable effect on the prevention of liver diseases, including HCC. One hypothesis suggests that coffee intake lowers serum levels of gamma-glutamyltransferase (GGT), which is associated with a lower incidence of HCC. It is estimated that more than 80% of HCC cases are attributable to four principal causes that are avoidable. It is difficult to make dietary recommendations, because it is unknown whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma. A diet rich that is in polyunsaturated fatty acids and, possibly, B-carotene could reduce the risk of HCC, and high dietary GL is associated with an increased risk independently of cirrhosis or diabetes.

AB - Hepatocellular carcinoma is the most common primary liver malignancy and is an international public health concern, constituting one of the most deadly cancers worldwide. Infection with hepatitis B virus and hepatitis C virus is a major risk factor for HCC in developed countries. Emerging evidence indicates that there are other important lifestyle factors that contribute to the international burden of HCC, such as alcohol consumption, diabetes, obesity, and the intake of aflotoxin-contaminated food. Obesity and diabetes are also likely to be risk factors for HCC, the most frequent subtype of liver cancer. The chief pathway by which obesity increases risk involves the association between obesity and nonalcoholic fatty liver disease (NAFLD). Coffee consumption has been studied extensively and appears to have a favorable effect on the prevention of liver diseases, including HCC. One hypothesis suggests that coffee intake lowers serum levels of gamma-glutamyltransferase (GGT), which is associated with a lower incidence of HCC. It is estimated that more than 80% of HCC cases are attributable to four principal causes that are avoidable. It is difficult to make dietary recommendations, because it is unknown whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma. A diet rich that is in polyunsaturated fatty acids and, possibly, B-carotene could reduce the risk of HCC, and high dietary GL is associated with an increased risk independently of cirrhosis or diabetes.

KW - Alcohol

KW - Coffee

KW - Diabetes mellitus

KW - Diet

KW - Hepatocellular carcinoma

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=79955625884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955625884&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 159

EP - 162

JO - Hepatitis Monthly

JF - Hepatitis Monthly

SN - 1735-143X

IS - 3

ER -