HCC in older patients

Brian I. Carr, Petr Pancoska, Robert A. Branch

Research output: Contribution to journalArticle

Abstract

Background: Hepatocellular carcinoma (HCC) is a heterogeneous disease, with many poorly-defined prognostic patient subsets. Identification of discrete subsets will aid rational patient and treatment selection. Methods: A database with 778 biopsy-proven, unresectable and untransplantable HCC patients who were followed from diagnosis till death was interrogated. Using a moving average algorithm, patients were ordered by survival and then survival cohorts were analyzed according to standard liver function and CT characteristic parameters. Results: We found characteristic age clustering groupings by survival. In the older age patients, two survival sub-groups were identified, with 45-80 days in one and 330-1,250 days survival in the other group. The longer surviving group had the lowest serum bilirubin and AFP levels and the lowest tumor mass. Remarkably, the trends for both AFP and bilirubin were similar, suggesting that they were not independent variables. This idea was supported by the similar correlation of typical AFP with GGTP, ALKP and SGOT levels. Conclusions: A large HCC cohort showed significant age clustering characteristics for survival, especially in older patients. AFP, bilirubin and age were found to be inter-related factors for HCC severity and survival.

Original languageEnglish
Pages (from-to)3584-3590
Number of pages7
JournalDigestive Diseases and Sciences
Volume55
Issue number12
DOIs
Publication statusPublished - Dec 2010

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Hepatocellular Carcinoma
Survival
Bilirubin
Cluster Analysis
gamma-Glutamyltransferase
Aspartate Aminotransferases
Patient Selection
Databases
Biopsy
Liver
Serum
Neoplasms

Keywords

  • AFP
  • Elderly
  • Hepatoma
  • Survival

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Carr, B. I., Pancoska, P., & Branch, R. A. (2010). HCC in older patients. Digestive Diseases and Sciences, 55(12), 3584-3590. https://doi.org/10.1007/s10620-010-1177-6

HCC in older patients. / Carr, Brian I.; Pancoska, Petr; Branch, Robert A.

In: Digestive Diseases and Sciences, Vol. 55, No. 12, 12.2010, p. 3584-3590.

Research output: Contribution to journalArticle

Carr, BI, Pancoska, P & Branch, RA 2010, 'HCC in older patients', Digestive Diseases and Sciences, vol. 55, no. 12, pp. 3584-3590. https://doi.org/10.1007/s10620-010-1177-6
Carr BI, Pancoska P, Branch RA. HCC in older patients. Digestive Diseases and Sciences. 2010 Dec;55(12):3584-3590. https://doi.org/10.1007/s10620-010-1177-6
Carr, Brian I. ; Pancoska, Petr ; Branch, Robert A. / HCC in older patients. In: Digestive Diseases and Sciences. 2010 ; Vol. 55, No. 12. pp. 3584-3590.
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