HCMOGT-1 Is a Novel Fusion Partner to PDGFRB in Juvenile Myelomonocytic Leukemia with t(5;17)(q33;p11.2)

Cristina Morerio, Maura Acquila, Cristina Rosanda, Annamaria Rapella, Carlo Dufour, Franco Locatelli, Emanuela Maserati, Francesco Pasquali, Claudio Panarello

Research output: Contribution to journalArticlepeer-review

Abstract

PDGFRB, a transmembrane tyrosine kinase receptor for platelet-derived growth factor, is constitutively activated by gene fusion with different partners in myeloproliferative/myelodysplastic disorders with peculiar clinical characteristics. Six alternative partner genes have been described thus far. In this study, we report the molecular cloning of a novel translocation t(5;17)(q33;p11.2) in a case of juvenile myelomonocytic leukemia. The novel partner gene was identified as HCMOGT-1 using 5′-rapid amplification of cDNA ends; fluorescence in situ hybridization and reverse transcriptase-PCR analyses confirmed that the translocation resulted in PDGFRB/HCMOGT-1 fusion. We show that the breakpoint of PDGFRB occurred at the same site of all previously reported PDGFRB translocations.

Original languageEnglish
Pages (from-to)2649-2651
Number of pages3
JournalCancer Research
Volume64
Issue number8
DOIs
Publication statusPublished - Apr 15 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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