Abstract
Flaviviridae-hepatitis C virus (HCV) and GB virus C/hepatitis G virus (GBV-C/HGV) - and human immunodeficiency virus (HIV) frequently show similar modes of transmission. HCV and GBV- C/HGV infection was assessed in 134 consecutive patients with evidence of HIV infection, living in Campania, Italy. Data obtained from this cohort were compared with those obtained from 252 age-and sex-matched HCV infected patients without evidence of HIV infection (HCV control group). Following enzymatic immunoassays, samples were tested for the presence of HCV-RNA by RT-PCR. The HCV-RNA positive sera were genotyped by LiPA procedure. The prevalence of HCV infection in HIV patients was 19.40% and the largest group of HIV-HCV co-infected patients (84.62%) was represented by intravenous drug users (IVDU). The distribution of HCV genotypes in HIV-HCV patients was different, compared to that observed in HCV control group. HCV genotypes la (50%) and 3a (23.08%) were more frequently detected in HIV-HCV patients, compared to HCV control group (5.16 and 5.56% for la and 3a, respectively). Conversely, HCV genotypes lb (55.70%) and 2a/2c (30.26%) were more represented in HCV control group, compared to HIV-HCV patients (15.38 and 0% for lb and 2a/2c, respectively). GBV-C/HGV seroprevalence was 41.04% in HIV patients and 6.54% in healthy control individuals. Differently from HCV, GBV-C/HGV infection did not correlate to a preferential risk behaviour in the HIV cohort. Comparative analysis of HCV and GBV-C/HGV infection indicates that the use of injecting drugs might play a key role in the epidemiology of HCV and, in particular, of la and 3a HCV genotypes, in HIV patients.
| Original language | English |
|---|---|
| Pages (from-to) | 801-807 |
| Number of pages | 7 |
| Journal | European Journal of Epidemiology |
| Volume | 17 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Flaviviridae infection
- GBV-C/HGV
- HCV genotypes
- HIV
- Southern Italy
ASJC Scopus subject areas
- Epidemiology
Cite this
HCV and GBV-C/HGV infection in HIV positive patients in Southern Italy. / Rendina, D.; Vigorita, E.; Bonavolta, R.; D'onofrio, M.; Iura, A.; Pietronigro, M. T T; Laccetti, R.; Bonadies, G.; Liuzzi, G.; Borgia, G.; Formisano, P.; Laccetti, P.; Portella, G.
In: European Journal of Epidemiology, Vol. 17, No. 9, 2001, p. 801-807.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HCV and GBV-C/HGV infection in HIV positive patients in Southern Italy
AU - Rendina, D.
AU - Vigorita, E.
AU - Bonavolta, R.
AU - D'onofrio, M.
AU - Iura, A.
AU - Pietronigro, M. T T
AU - Laccetti, R.
AU - Bonadies, G.
AU - Liuzzi, G.
AU - Borgia, G.
AU - Formisano, P.
AU - Laccetti, P.
AU - Portella, G.
PY - 2001
Y1 - 2001
N2 - Flaviviridae-hepatitis C virus (HCV) and GB virus C/hepatitis G virus (GBV-C/HGV) - and human immunodeficiency virus (HIV) frequently show similar modes of transmission. HCV and GBV- C/HGV infection was assessed in 134 consecutive patients with evidence of HIV infection, living in Campania, Italy. Data obtained from this cohort were compared with those obtained from 252 age-and sex-matched HCV infected patients without evidence of HIV infection (HCV control group). Following enzymatic immunoassays, samples were tested for the presence of HCV-RNA by RT-PCR. The HCV-RNA positive sera were genotyped by LiPA procedure. The prevalence of HCV infection in HIV patients was 19.40% and the largest group of HIV-HCV co-infected patients (84.62%) was represented by intravenous drug users (IVDU). The distribution of HCV genotypes in HIV-HCV patients was different, compared to that observed in HCV control group. HCV genotypes la (50%) and 3a (23.08%) were more frequently detected in HIV-HCV patients, compared to HCV control group (5.16 and 5.56% for la and 3a, respectively). Conversely, HCV genotypes lb (55.70%) and 2a/2c (30.26%) were more represented in HCV control group, compared to HIV-HCV patients (15.38 and 0% for lb and 2a/2c, respectively). GBV-C/HGV seroprevalence was 41.04% in HIV patients and 6.54% in healthy control individuals. Differently from HCV, GBV-C/HGV infection did not correlate to a preferential risk behaviour in the HIV cohort. Comparative analysis of HCV and GBV-C/HGV infection indicates that the use of injecting drugs might play a key role in the epidemiology of HCV and, in particular, of la and 3a HCV genotypes, in HIV patients.
AB - Flaviviridae-hepatitis C virus (HCV) and GB virus C/hepatitis G virus (GBV-C/HGV) - and human immunodeficiency virus (HIV) frequently show similar modes of transmission. HCV and GBV- C/HGV infection was assessed in 134 consecutive patients with evidence of HIV infection, living in Campania, Italy. Data obtained from this cohort were compared with those obtained from 252 age-and sex-matched HCV infected patients without evidence of HIV infection (HCV control group). Following enzymatic immunoassays, samples were tested for the presence of HCV-RNA by RT-PCR. The HCV-RNA positive sera were genotyped by LiPA procedure. The prevalence of HCV infection in HIV patients was 19.40% and the largest group of HIV-HCV co-infected patients (84.62%) was represented by intravenous drug users (IVDU). The distribution of HCV genotypes in HIV-HCV patients was different, compared to that observed in HCV control group. HCV genotypes la (50%) and 3a (23.08%) were more frequently detected in HIV-HCV patients, compared to HCV control group (5.16 and 5.56% for la and 3a, respectively). Conversely, HCV genotypes lb (55.70%) and 2a/2c (30.26%) were more represented in HCV control group, compared to HIV-HCV patients (15.38 and 0% for lb and 2a/2c, respectively). GBV-C/HGV seroprevalence was 41.04% in HIV patients and 6.54% in healthy control individuals. Differently from HCV, GBV-C/HGV infection did not correlate to a preferential risk behaviour in the HIV cohort. Comparative analysis of HCV and GBV-C/HGV infection indicates that the use of injecting drugs might play a key role in the epidemiology of HCV and, in particular, of la and 3a HCV genotypes, in HIV patients.
KW - Flaviviridae infection
KW - GBV-C/HGV
KW - HCV genotypes
KW - HIV
KW - Southern Italy
UR - http://www.scopus.com/inward/record.url?scp=0035740151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035740151&partnerID=8YFLogxK
U2 - 10.1023/A:1015679929395
DO - 10.1023/A:1015679929395
M3 - Article
C2 - 12081097
AN - SCOPUS:0035740151
VL - 17
SP - 801
EP - 807
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
IS - 9
ER -