GENOTIPI DI HCV E HCV III-IV LIKE IN PAZIENTI CRONICAMENTE INFETTI: PREVALENZA E CORRELAZIONE CON IL PATTERN ANTICORPALE

Translated title of the contribution: HCV and HCV III-IV like genotypes in chronically infected patients. Prevalence and correlation with antibody pattern

M. Crovatto, G. Pozzato, M. L. Modolo, S. Ceselli, P. Martelli, B. Pivetta, M. Moretti, M. Giacca, G. Grassi, P. Casarin, C. Mazzaro, G. Mazzi, C. Donada, T. Lacchin, A. Faelli, C. Braida, B. Chiarotto, G. F. Santini

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus strains obtained from 170 sera of patients with chronic non-A non-B hepatitis, hepatocellular carcinoma, cryoglobulinaemia and Waldenstrom's disease and asymptomatic carriers were grouped into four genotypes (I, II, III, IV) by core-gene sequence amplification by polymerase chain reaction with type-specific primers: 5(2.9%) were type I HCV, 102(60%) type II, 6(3.6%) were type III, 7(4.1%) were type IV, 33(19.4%) had a mixture of two, three or four genotypes, 17 (10%) were not classifiable. The analysis of 3 mixed-genotype and 11 not-classifiable sera demonstrated the presence of type V in three samples and a new genotype, called provisionally genotype III-IV like, in the others. Studies on the molecular and pathogenetic characteristics of the new genotype are now in progress. Evaluation of antibody patterns revealed genotype dependence for anti c100-3 and 5-1-1 antibodies.

Translated title of the contributionHCV and HCV III-IV like genotypes in chronically infected patients. Prevalence and correlation with antibody pattern
Original languageItalian
Pages (from-to)8-13
Number of pages6
JournalMicrobiologia Medica
Volume10
Issue number1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Microbiology (medical)

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    Crovatto, M., Pozzato, G., Modolo, M. L., Ceselli, S., Martelli, P., Pivetta, B., Moretti, M., Giacca, M., Grassi, G., Casarin, P., Mazzaro, C., Mazzi, G., Donada, C., Lacchin, T., Faelli, A., Braida, C., Chiarotto, B., & Santini, G. F. (1995). GENOTIPI DI HCV E HCV III-IV LIKE IN PAZIENTI CRONICAMENTE INFETTI: PREVALENZA E CORRELAZIONE CON IL PATTERN ANTICORPALE. Microbiologia Medica, 10(1), 8-13.