Hepatitis C virus strains obtained from 170 sera of patients with chronic non-A non-B hepatitis, hepatocellular carcinoma, cryoglobulinaemia and Waldenstrom's disease and asymptomatic carriers were grouped into four genotypes (I, II, III, IV) by core-gene sequence amplification by polymerase chain reaction with type-specific primers: 5(2.9%) were type I HCV, 102(60%) type II, 6(3.6%) were type III, 7(4.1%) were type IV, 33(19.4%) had a mixture of two, three or four genotypes, 17 (10%) were not classifiable. The analysis of 3 mixed-genotype and 11 not-classifiable sera demonstrated the presence of type V in three samples and a new genotype, called provisionally genotype III-IV like, in the others. Studies on the molecular and pathogenetic characteristics of the new genotype are now in progress. Evaluation of antibody patterns revealed genotype dependence for anti c100-3 and 5-1-1 antibodies.
|Translated title of the contribution||HCV and HCV III-IV like genotypes in chronically infected patients. Prevalence and correlation with antibody pattern|
|Number of pages||6|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Microbiology (medical)