HCV infection in a patient with hyper-IgM syndrome

Isabella Quinti, Antonello Giovannetti, Roberto Paganelli, Leopoldo Paolo Pucillo, Anna Rita Varani, Giovanni Ricci, Enrico Scala, Franco Pandolfi, Milvia Casato, Fernando Aiuti

Research output: Contribution to journalArticlepeer-review


The association between an acquired form of hyper-IgM syndrome and a chronic hepatitis C virus (HCV) infection in a 71-year-old female patient is described. Both diseases were diagnosed at the age of 58 years. She was started on intramuscular and then intravenous immunoglobulin replacement therapy. HCV RNA was detected in 1992. The patient remained in well-balanced clinical condition until 1994, when total and specific anti-HCV IgM levels increased and the patient developed an IgMκ monoclonal gammopathy. Adherent cells and B cells were HCV RNA positive, while T cells were HCV RNA negative. Anti-IgM reactivity was specifically directed to the core antigen of the HCV. The patient we describe showed a picture of a late-onset form of hypogammaglobulinemia with a progressive increase in IgM antibodies, possibly due to the concomitant HCV infection. It is possible that the immunodeficiency might also result from the HCV infection, with formation of specific antibodies belonging to the IgM class, and that the worsening of the clinical condition may be directly related to the persistent viral infection.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalJournal of Clinical Immunology
Issue number6
Publication statusPublished - 1996


  • Hepatitis C virus
  • IgM
  • Immunodeficiency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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