HDL Cholesterol is Independently Associated with Cognitive Function in Males but Not in Females within a Cohort of Nonagenarians: The Mugello Study

The Mugello Study Working Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To investigate the possible relationship between lipid profile and cognitive functions in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues. Design: Cross-sectional survey. Setting: This study focused on oldest old community-dwelling participants. Participants: Three hundred twenty-five nonagenarians (218 F, median age: 92 years). Measurements: Participants were evaluated through laboratory, instrumental examinations and questionnaires concerning lifestyle, dietary habits and cognitive status. Results: Females are older, with a lower level of education, live more prevalently on their own and have higher values for total cholesterol and high-density lipoprotein cholesterol (HDL) compared to males. With regard to functional and cognitive measures females report a significantly lower skill level in the physical activity performance, with a level of independence that is better for both basic and instrumental activities. In order to investigate whether there was an association between lipid variables and cognitive function as measured by the Mini-Mental State Examination a multiple regression analysis was performed with adjustments for confounding variables based on gender. In males, HDL cholesterol showed a significant relationship with Mini-Mental State Examination after a complete adjustment with years of education, physical activity performance and daily living activities (β = 0.174; p=0.037). In females HDL cholesterol showed a significant association only in the model adjusted for age and body mass index, losing its associations as soon as the cohabitation state and the depression status entered the model. Conclusion: Our results support the hypothesis that HDL cholesterol is significantly linked to cognitive functions, especially in males of a cohort of very old people.

Original languageEnglish
JournalJournal of Nutrition, Health and Aging
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Cognition
HDL Cholesterol
Cholesterol
Activities of Daily Living
Exercise
Independent Living
Lipids
Education
Social Adjustment
Confounding Factors (Epidemiology)
Feeding Behavior
Geriatrics
Life Style
Epidemiologic Studies
Body Mass Index
Cross-Sectional Studies
Regression Analysis
Depression
Health

Keywords

  • cholesterol
  • dementia
  • elderly
  • Lipid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

@article{532c1883200d48158b57cfc49e3ffc99,
title = "HDL Cholesterol is Independently Associated with Cognitive Function in Males but Not in Females within a Cohort of Nonagenarians: The Mugello Study",
abstract = "Objectives: To investigate the possible relationship between lipid profile and cognitive functions in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues. Design: Cross-sectional survey. Setting: This study focused on oldest old community-dwelling participants. Participants: Three hundred twenty-five nonagenarians (218 F, median age: 92 years). Measurements: Participants were evaluated through laboratory, instrumental examinations and questionnaires concerning lifestyle, dietary habits and cognitive status. Results: Females are older, with a lower level of education, live more prevalently on their own and have higher values for total cholesterol and high-density lipoprotein cholesterol (HDL) compared to males. With regard to functional and cognitive measures females report a significantly lower skill level in the physical activity performance, with a level of independence that is better for both basic and instrumental activities. In order to investigate whether there was an association between lipid variables and cognitive function as measured by the Mini-Mental State Examination a multiple regression analysis was performed with adjustments for confounding variables based on gender. In males, HDL cholesterol showed a significant relationship with Mini-Mental State Examination after a complete adjustment with years of education, physical activity performance and daily living activities (β = 0.174; p=0.037). In females HDL cholesterol showed a significant association only in the model adjusted for age and body mass index, losing its associations as soon as the cohabitation state and the depression status entered the model. Conclusion: Our results support the hypothesis that HDL cholesterol is significantly linked to cognitive functions, especially in males of a cohort of very old people.",
keywords = "cholesterol, dementia, elderly, Lipid",
author = "Silvia Pancani and F. Sofi and F. Cecchi and C. Macchi and {The Mugello Study Working Group}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12603-019-1203-0",
language = "English",
journal = "Journal of Nutrition, Health and Aging",
issn = "1279-7707",
publisher = "Springer Paris",

}

TY - JOUR

T1 - HDL Cholesterol is Independently Associated with Cognitive Function in Males but Not in Females within a Cohort of Nonagenarians

T2 - The Mugello Study

AU - Pancani, Silvia

AU - Sofi, F.

AU - Cecchi, F.

AU - Macchi, C.

AU - The Mugello Study Working Group

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To investigate the possible relationship between lipid profile and cognitive functions in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues. Design: Cross-sectional survey. Setting: This study focused on oldest old community-dwelling participants. Participants: Three hundred twenty-five nonagenarians (218 F, median age: 92 years). Measurements: Participants were evaluated through laboratory, instrumental examinations and questionnaires concerning lifestyle, dietary habits and cognitive status. Results: Females are older, with a lower level of education, live more prevalently on their own and have higher values for total cholesterol and high-density lipoprotein cholesterol (HDL) compared to males. With regard to functional and cognitive measures females report a significantly lower skill level in the physical activity performance, with a level of independence that is better for both basic and instrumental activities. In order to investigate whether there was an association between lipid variables and cognitive function as measured by the Mini-Mental State Examination a multiple regression analysis was performed with adjustments for confounding variables based on gender. In males, HDL cholesterol showed a significant relationship with Mini-Mental State Examination after a complete adjustment with years of education, physical activity performance and daily living activities (β = 0.174; p=0.037). In females HDL cholesterol showed a significant association only in the model adjusted for age and body mass index, losing its associations as soon as the cohabitation state and the depression status entered the model. Conclusion: Our results support the hypothesis that HDL cholesterol is significantly linked to cognitive functions, especially in males of a cohort of very old people.

AB - Objectives: To investigate the possible relationship between lipid profile and cognitive functions in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues. Design: Cross-sectional survey. Setting: This study focused on oldest old community-dwelling participants. Participants: Three hundred twenty-five nonagenarians (218 F, median age: 92 years). Measurements: Participants were evaluated through laboratory, instrumental examinations and questionnaires concerning lifestyle, dietary habits and cognitive status. Results: Females are older, with a lower level of education, live more prevalently on their own and have higher values for total cholesterol and high-density lipoprotein cholesterol (HDL) compared to males. With regard to functional and cognitive measures females report a significantly lower skill level in the physical activity performance, with a level of independence that is better for both basic and instrumental activities. In order to investigate whether there was an association between lipid variables and cognitive function as measured by the Mini-Mental State Examination a multiple regression analysis was performed with adjustments for confounding variables based on gender. In males, HDL cholesterol showed a significant relationship with Mini-Mental State Examination after a complete adjustment with years of education, physical activity performance and daily living activities (β = 0.174; p=0.037). In females HDL cholesterol showed a significant association only in the model adjusted for age and body mass index, losing its associations as soon as the cohabitation state and the depression status entered the model. Conclusion: Our results support the hypothesis that HDL cholesterol is significantly linked to cognitive functions, especially in males of a cohort of very old people.

KW - cholesterol

KW - dementia

KW - elderly

KW - Lipid

UR - http://www.scopus.com/inward/record.url?scp=85066159244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066159244&partnerID=8YFLogxK

U2 - 10.1007/s12603-019-1203-0

DO - 10.1007/s12603-019-1203-0

M3 - Article

AN - SCOPUS:85066159244

JO - Journal of Nutrition, Health and Aging

JF - Journal of Nutrition, Health and Aging

SN - 1279-7707

ER -