HDLs, immunity, and atherosclerosis

Giuseppe D. Norata, Angela Pirillo, Alberico L. Catapano

Research output: Contribution to journalArticle

Abstract

Purpose of Review: HDLs possess several physiological activities that may explain their antiatherosclerotic properties. Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. Recent Findings: The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. HDL also acts as a reservoir for a number of biologically active substances that may impact the immune system, and as the HDL composition varies to a large extent during inflammation. Summary: The understanding of how these interactions take place and how biologically active substances can be delivered to relevant targets during atherogenesis is of great interest and may provide a better understanding for the role of HDL in atherogenesis.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalCurrent Opinion in Lipidology
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • apoA-I
  • high-density lipoprotein
  • immune response
  • sphingosine-1-phosphate

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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