TY - JOUR
T1 - Head and neck and esophageal cancers after liver transplant
T2 - Results from a multicenter cohort study. Italy, 1997-2010
AU - Piselli, Pierluca
AU - Burra, Patrizia
AU - Lauro, Augusto
AU - Baccarani, Umberto
AU - Ettorre, Giuseppe M.
AU - Vizzini, Giovanni B.
AU - Rendina, Maria
AU - Rossi, Massimo
AU - Tisone, Giuseppe
AU - Zamboni, Fausto
AU - Bortoluzzi, Ilaria
AU - Pinna, Antonio D.
AU - Risaliti, Andrea
AU - Galatioto, Laura
AU - Vennarecci, Giovanni
AU - Di Leo, Alfredo
AU - Nudo, Francesco
AU - Sforza, Daniele
AU - Fantola, Giovanni
AU - Cimaglia, Claudia
AU - Verdirosi, Diana
AU - Virdone, Saverio
AU - Serraino, Diego
PY - 2015/7/1
Y1 - 2015/7/1
N2 - This study quantified the risk of head and neck (HN) and esophageal cancers in 2770 Italian liver transplant (LT) recipients. A total of 186 post-transplant cancers were diagnosed - including 32 cases of HN cancers and nine cases of esophageal carcinoma. The 10-year cumulative risk for HN and esophageal carcinoma was 2.59%. Overall, HN cancers were nearly fivefold more frequent in LT recipients than expected (standardized incidence ratios - SIR=4.7, 95% CI: 3.2-6.6), while esophageal carcinoma was ninefold more frequent (SIR=9.1, 95% CI: 4.1-17.2). SIRs ranged from 11.8 in LT with alcoholic liver disease (ALD) to 1.8 for LT without ALD for HN cancers, and from 23.7 to 2.9, respectively, for esophageal carcinoma. Particularly elevated SIRs in LT with ALD were noted for carcinomas of tongue (23.0) or larynx (13.7). Our findings confirmed and quantified the large cancer excess risk in LT recipients with ALD. The risk magnitude and the prevalence of ALD herein documented stress the need of timely and specifically organized programs for the early diagnosis of cancer among LT recipients, particularly for high-risk recipients like those with ALD.
AB - This study quantified the risk of head and neck (HN) and esophageal cancers in 2770 Italian liver transplant (LT) recipients. A total of 186 post-transplant cancers were diagnosed - including 32 cases of HN cancers and nine cases of esophageal carcinoma. The 10-year cumulative risk for HN and esophageal carcinoma was 2.59%. Overall, HN cancers were nearly fivefold more frequent in LT recipients than expected (standardized incidence ratios - SIR=4.7, 95% CI: 3.2-6.6), while esophageal carcinoma was ninefold more frequent (SIR=9.1, 95% CI: 4.1-17.2). SIRs ranged from 11.8 in LT with alcoholic liver disease (ALD) to 1.8 for LT without ALD for HN cancers, and from 23.7 to 2.9, respectively, for esophageal carcinoma. Particularly elevated SIRs in LT with ALD were noted for carcinomas of tongue (23.0) or larynx (13.7). Our findings confirmed and quantified the large cancer excess risk in LT recipients with ALD. The risk magnitude and the prevalence of ALD herein documented stress the need of timely and specifically organized programs for the early diagnosis of cancer among LT recipients, particularly for high-risk recipients like those with ALD.
KW - aerodigestive cancers
KW - cancer risk
KW - immunosuppression
KW - liver cirrhosis
KW - liver diseases
KW - oncogenic viruses
KW - organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=84930472933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930472933&partnerID=8YFLogxK
U2 - 10.1111/tri.12555
DO - 10.1111/tri.12555
M3 - Article
C2 - 25778395
AN - SCOPUS:84930472933
VL - 28
SP - 841
EP - 848
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 7
ER -