Head pain mechanisms and serotonin in human

A study on m-chlorophenylpiperazine-induced headache and possible no involvement

M. Leone, A. Attanasio, D. D'Amico, L. Grazzi, F. Moschiano, G. Bussone

Research output: Contribution to journalArticle

Abstract

m-Chlorophenylpiperazine (m-CPP), a 5-HTergic agonist, is a well known migrainous headache provoking agent, probably mediated by NO release. In this study m-CPP was given to 97 subjects, including cluster headache (CH) and migraine patients, to test the hypothesis of an altered 5-HT activity/sensitivity in these pathologies. Sixty-one episodic CH patients, 44 in cluster period and 17 in remission, 10 migraine without aura sufferers, 7 low back pain (LBP) patients and 19 healthy subjects were investigated. A single oral dose of m-CPP, 0.5 mg/Kg, was given. m-CPP plasma levels were not significantly different between the 5 groups. Migrainous headache was reported by 2 healthy subjects (10.5%), 3 cluster period CH patients (6.8%), 2 CH patients in remission (11.7%), 2 migraineurs (20%) and 1 LBP patient (14.2%). Eighteen cluster period CH patients (41%) had a CH attack outside the typical hour of appearance, 2 ±0.2 hours (mean ±sem) after m-CPP administration. This study suggests that 5-HTergic stimulation, in particular of 5-HT2 C/B receptors, play a key role both in migraine and, above all, in cluster headache mechanisms. Nitric oxide release probably is the common factor inducing head pain in both the headache forms.

Original languageEnglish
Pages (from-to)45
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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Cluster Headache
Headache
Serotonin
Low Back Pain
Migraine Disorders
Healthy Volunteers
Migraine without Aura
1-(3-chlorophenyl)piperazine
Nitric Oxide
Pathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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title = "Head pain mechanisms and serotonin in human: A study on m-chlorophenylpiperazine-induced headache and possible no involvement",
abstract = "m-Chlorophenylpiperazine (m-CPP), a 5-HTergic agonist, is a well known migrainous headache provoking agent, probably mediated by NO release. In this study m-CPP was given to 97 subjects, including cluster headache (CH) and migraine patients, to test the hypothesis of an altered 5-HT activity/sensitivity in these pathologies. Sixty-one episodic CH patients, 44 in cluster period and 17 in remission, 10 migraine without aura sufferers, 7 low back pain (LBP) patients and 19 healthy subjects were investigated. A single oral dose of m-CPP, 0.5 mg/Kg, was given. m-CPP plasma levels were not significantly different between the 5 groups. Migrainous headache was reported by 2 healthy subjects (10.5{\%}), 3 cluster period CH patients (6.8{\%}), 2 CH patients in remission (11.7{\%}), 2 migraineurs (20{\%}) and 1 LBP patient (14.2{\%}). Eighteen cluster period CH patients (41{\%}) had a CH attack outside the typical hour of appearance, 2 ±0.2 hours (mean ±sem) after m-CPP administration. This study suggests that 5-HTergic stimulation, in particular of 5-HT2 C/B receptors, play a key role both in migraine and, above all, in cluster headache mechanisms. Nitric oxide release probably is the common factor inducing head pain in both the headache forms.",
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T2 - A study on m-chlorophenylpiperazine-induced headache and possible no involvement

AU - Leone, M.

AU - Attanasio, A.

AU - D'Amico, D.

AU - Grazzi, L.

AU - Moschiano, F.

AU - Bussone, G.

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