Head to head comparison of nomograms predicting probability of lymph node invasion of prostate cancer in patients undergoing extended pelvic lymph node dissection

Jochen Walz, Franck Bladou, Bertrand Rousseau, Julien Laroche, Naji Salem, Gwenaelle Gravis, Alberto Briganti, Felix K H Chun, Pierre I. Karakiewicz, Georges Fournier

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To validate the Briganti nomogram and compare it with 2 current lymph node invasion (LNI) nomograms (the Cagiannos nomogram and the updated 2007 Partin tables). The Briganti nomogram predicts the probability of LNI in patients undergoing extended pelvic lymph node dissection (EPLND) during radical prostatectomy for prostate cancer. Methods: Irrespective of the risk of LNI, 173 consecutive patients were treated for localized prostate cancer with radical laparoscopic prostatectomy and EPLND. The area under the receiver operating characteristics curve was used to estimate the predictive accuracy of the nomograms, and calibration plots were used for comparisons between the predicted and observed probabilities of LNI. Results: The median number of nodes removed was 15 (range 10-34). Of the 173 patients, 12 (6.9%) had LNI. The Briganti nomogram achieved a receiver operating characteristic curve of 0.88 versus 0.83 with the Cagiannos nomogram and 0.84 with the 2007 Partin tables. The difference in predictive accuracy was not statistically significant (P

Original languageEnglish
Pages (from-to)546-551
Number of pages6
JournalUrology
Volume79
Issue number3
DOIs
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Urology

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