Head-to-head comparison of two popular cortical thickness extraction algorithms: A cross-sectional and longitudinal study

Alberto Redolfi, David Manset, Frederik Barkhof, Lars Olof Wahlund, Tristan Glatard, Jean Franc¸ois Mangin, Giovanni B. Frisoni

Research output: Contribution to journalArticle

Abstract

Background and Purpose: The measurement of cortical shrinkage is a candidate marker of disease progression in Alzheimer's. This study evaluated the performance of two pipelines: Civet-CLASP (v1.1.9) and Freesurfer (v5.3.0). Methods: Images from 185 ADNI1 cases (69 elderly controls (CTR), 37 stable MCI (sMCI), 27 progressive MCI (pMCI), and 52 Alzheimer (AD) patients) scanned at baseline, month 12, and month 24 were processed using the two pipelines and two interconnected e-infrastructures: neuGRID (https://neugrid4you.eu) and VIP (http://vip.creatis.insa-lyon.fr). The vertex-by-vertex cross-algorithm comparison was made possible applying the 3D gradient vector flow (GVF) and closest point search (CPS) techniques. Results: The cortical thickness measured with Freesurfer was systematically lower by one third if compared to Civet 's. Cross-sectionally, Freesurfer's effect size was significantly different in the posterior division of the temporal fusiform cortex. Both pipelines were weakly or mildly correlated with the Mini Mental State Examination score (MMSE) and the hippocampal volumetry. Civet differed significantly from Freesurfer in large frontal, parietal, temporal and occipital regions (p

Original languageEnglish
Article numbere0117692
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 17 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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