Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor

Maria Elena Flacco, Lamberto Manzoli, Stefania Boccia, Lorenzo Capasso, Katina Aleksovska, Annalisa Rosso, Giacomo Scaioli, Corrado De Vito, Roberta Siliquini, Paolo Villari, John P A Ioannidis

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives To map the current status of head-to-head comparative randomized evidence and to assess whether funding may impact on trial design and results. Study Design and Setting From a 50% random sample of the randomized controlled trials (RCTs) published in journals indexed in PubMed during 2011, we selected the trials with

Original languageEnglish
Pages (from-to)811-820
Number of pages10
JournalJournal of Clinical Epidemiology
Volume68
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Conflict of interest
  • Cross-sectional study
  • Head-to-head comparison
  • Industry sponsorship
  • Noninferiority trials
  • Randomized controlled trials

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

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