Abstract
Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.
| Original language | English |
|---|---|
| Pages (from-to) | 140-143 |
| Number of pages | 4 |
| Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
| Volume | 161 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- Headache
- Migraine
- Newborn small for gestational age
- Preterm delivery
- Tension-type headache
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Headache and adverse pregnancy outcomes : A prospective study. / Marozio, Luca; Facchinetti, Fabio; Allais, Gianni; Nappi, Rossella E.; Enrietti, Marta; Neri, Isabella; Picardo, Elisa; Benedetto, Chiara.
In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 161, No. 2, 04.2012, p. 140-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Headache and adverse pregnancy outcomes
T2 - A prospective study
AU - Marozio, Luca
AU - Facchinetti, Fabio
AU - Allais, Gianni
AU - Nappi, Rossella E.
AU - Enrietti, Marta
AU - Neri, Isabella
AU - Picardo, Elisa
AU - Benedetto, Chiara
PY - 2012/4
Y1 - 2012/4
N2 - Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.
AB - Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.
KW - Headache
KW - Migraine
KW - Newborn small for gestational age
KW - Preterm delivery
KW - Tension-type headache
UR - http://www.scopus.com/inward/record.url?scp=84858438090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858438090&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2011.12.030
DO - 10.1016/j.ejogrb.2011.12.030
M3 - Article
C2 - 22280825
AN - SCOPUS:84858438090
VL - 161
SP - 140
EP - 143
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 2
ER -