Headache and adverse pregnancy outcomes

A prospective study

Luca Marozio, Fabio Facchinetti, Gianni Allais, Rossella E. Nappi, Marta Enrietti, Isabella Neri, Elisa Picardo, Chiara Benedetto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume161
Issue number2
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Pregnancy Outcome
Headache
Prospective Studies
Gestational Age
Tension-Type Headache
Migraine Disorders
Birth Weight
Cesarean Section
Pregnant Women
Outcome Assessment (Health Care)
Newborn Infant
Induced Labor
High-Risk Pregnancy
Pregnancy
Headache Disorders
Pre-Eclampsia
Tertiary Care Centers
Italy
Cohort Studies
Multivariate Analysis

Keywords

  • Headache
  • Migraine
  • Newborn small for gestational age
  • Preterm delivery
  • Tension-type headache

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Headache and adverse pregnancy outcomes : A prospective study. / Marozio, Luca; Facchinetti, Fabio; Allais, Gianni; Nappi, Rossella E.; Enrietti, Marta; Neri, Isabella; Picardo, Elisa; Benedetto, Chiara.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 161, No. 2, 04.2012, p. 140-143.

Research output: Contribution to journalArticle

Marozio, L, Facchinetti, F, Allais, G, Nappi, RE, Enrietti, M, Neri, I, Picardo, E & Benedetto, C 2012, 'Headache and adverse pregnancy outcomes: A prospective study', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 161, no. 2, pp. 140-143. https://doi.org/10.1016/j.ejogrb.2011.12.030
Marozio, Luca ; Facchinetti, Fabio ; Allais, Gianni ; Nappi, Rossella E. ; Enrietti, Marta ; Neri, Isabella ; Picardo, Elisa ; Benedetto, Chiara. / Headache and adverse pregnancy outcomes : A prospective study. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 2012 ; Vol. 161, No. 2. pp. 140-143.
@article{798538db375e453db00baacb3240ae81,
title = "Headache and adverse pregnancy outcomes: A prospective study",
abstract = "Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95{\%} confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95{\%} CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.",
keywords = "Headache, Migraine, Newborn small for gestational age, Preterm delivery, Tension-type headache",
author = "Luca Marozio and Fabio Facchinetti and Gianni Allais and Nappi, {Rossella E.} and Marta Enrietti and Isabella Neri and Elisa Picardo and Chiara Benedetto",
year = "2012",
month = "4",
doi = "10.1016/j.ejogrb.2011.12.030",
language = "English",
volume = "161",
pages = "140--143",
journal = "European Journal of Obstetrics, Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Headache and adverse pregnancy outcomes

T2 - A prospective study

AU - Marozio, Luca

AU - Facchinetti, Fabio

AU - Allais, Gianni

AU - Nappi, Rossella E.

AU - Enrietti, Marta

AU - Neri, Isabella

AU - Picardo, Elisa

AU - Benedetto, Chiara

PY - 2012/4

Y1 - 2012/4

N2 - Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.

AB - Objective: To investigate the association between headache, namely migraine and tension-type headache, and adverse pregnancy outcome. Study design: Prospective cohort study conducted in three tertiary care centres in Italy: 376 pregnant women suffering from headache and 326 non-headache pregnant women as controls were recruited. The diagnosis of headache was made at the beginning of pregnancy, according to the criteria of the International Classification of Headache Disorders (ICHD-II). Women were followed up until delivery, and gestational age at delivery, mode of delivery, indications for operative delivery or caesarean section, birth weight, and centile of neonatal weight at birth were carefully recorded. Main outcome measures of the study were: preterm delivery, newborns small for gestational age, and foetal losses. Odds ratios and 95% confidence intervals were calculated. Results: The incidence of preterm delivery (Adj OR, 95% CI 2.74, 1.27-5.91) was significantly higher in women suffering from headache than in controls. There was no statistically significant difference in small for gestational age newborns between the groups. Fewer women in the headache group had preterm elective caesarean section or induction of labour, than did controls, indicating a higher chance of spontaneous preterm delivery. Multivariate analysis showed that the association between headache, either migraine or tension-type, and adverse perinatal outcomes was statistically significant regardless of pre-eclampsia. Conclusions: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.

KW - Headache

KW - Migraine

KW - Newborn small for gestational age

KW - Preterm delivery

KW - Tension-type headache

UR - http://www.scopus.com/inward/record.url?scp=84858438090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858438090&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2011.12.030

DO - 10.1016/j.ejogrb.2011.12.030

M3 - Article

VL - 161

SP - 140

EP - 143

JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

SN - 0028-2243

IS - 2

ER -