Abstract
The relationship between headache and seizures is a complicated one, since these two conditions are related in numerous ways.Although the nature of this association is unclear, several plausible explanations exist: the two disorders coexist by chance; headache is part (or even the sole ictal phenomenon) of seizures or the post-ictal state; both disorders share a common underlying etiology; and epilepsy mimics the symptoms of migraine (as in benign childhood epilepsy).Seizures and headaches as well as their respective primary syndromes (epilepsy and headache/migraine) share several pathophysiological mechanisms. These mechanisms especially involve neurotransmitter and ion channel dysfunctions. Also, photosensitivity seems to play a role in the connection. In order to improve the care for patients with a clinical connection between migraine and epilepsy, it is necessary to try to understand more accurately the exact pathophysiological point of connection between these two conditions. Both experimental and clinical measures are required to better understand this relationship. The development of animal models, molecular studies defining more precise genotype/phenotype correlations, and multicenter clinical studies with revision of clinical criteria for headache/epilepsy-related disorders represent the start for planning future translational research.In this paper, we review the relationship between migraine and epilepsy in terms of epidemiology and pathophysiology with regard to translational research and clinical correlations and classification.This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research".
| Original language | English |
|---|---|
| Pages (from-to) | 386-393 |
| Number of pages | 8 |
| Journal | Epilepsy and Behavior |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- Autonomic seizures
- Autonomic status epilepticus
- Epilepsy
- Headache
- Ictal epileptic headache
- Migraine
- Migralepsy
- Tension-type headache
ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Neurology
Cite this
"Headache and epilepsy" - How are they connected? / Papetti, Laura; Nicita, Francesco; Parisi, Pasquale; Spalice, Alberto; Villa, Maria Pia; Kasteleijn-Nolst Trenité, D. G A.
In: Epilepsy and Behavior, Vol. 26, No. 3, 03.2013, p. 386-393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - "Headache and epilepsy" - How are they connected?
AU - Papetti, Laura
AU - Nicita, Francesco
AU - Parisi, Pasquale
AU - Spalice, Alberto
AU - Villa, Maria Pia
AU - Kasteleijn-Nolst Trenité, D. G A
PY - 2013/3
Y1 - 2013/3
N2 - The relationship between headache and seizures is a complicated one, since these two conditions are related in numerous ways.Although the nature of this association is unclear, several plausible explanations exist: the two disorders coexist by chance; headache is part (or even the sole ictal phenomenon) of seizures or the post-ictal state; both disorders share a common underlying etiology; and epilepsy mimics the symptoms of migraine (as in benign childhood epilepsy).Seizures and headaches as well as their respective primary syndromes (epilepsy and headache/migraine) share several pathophysiological mechanisms. These mechanisms especially involve neurotransmitter and ion channel dysfunctions. Also, photosensitivity seems to play a role in the connection. In order to improve the care for patients with a clinical connection between migraine and epilepsy, it is necessary to try to understand more accurately the exact pathophysiological point of connection between these two conditions. Both experimental and clinical measures are required to better understand this relationship. The development of animal models, molecular studies defining more precise genotype/phenotype correlations, and multicenter clinical studies with revision of clinical criteria for headache/epilepsy-related disorders represent the start for planning future translational research.In this paper, we review the relationship between migraine and epilepsy in terms of epidemiology and pathophysiology with regard to translational research and clinical correlations and classification.This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research".
AB - The relationship between headache and seizures is a complicated one, since these two conditions are related in numerous ways.Although the nature of this association is unclear, several plausible explanations exist: the two disorders coexist by chance; headache is part (or even the sole ictal phenomenon) of seizures or the post-ictal state; both disorders share a common underlying etiology; and epilepsy mimics the symptoms of migraine (as in benign childhood epilepsy).Seizures and headaches as well as their respective primary syndromes (epilepsy and headache/migraine) share several pathophysiological mechanisms. These mechanisms especially involve neurotransmitter and ion channel dysfunctions. Also, photosensitivity seems to play a role in the connection. In order to improve the care for patients with a clinical connection between migraine and epilepsy, it is necessary to try to understand more accurately the exact pathophysiological point of connection between these two conditions. Both experimental and clinical measures are required to better understand this relationship. The development of animal models, molecular studies defining more precise genotype/phenotype correlations, and multicenter clinical studies with revision of clinical criteria for headache/epilepsy-related disorders represent the start for planning future translational research.In this paper, we review the relationship between migraine and epilepsy in terms of epidemiology and pathophysiology with regard to translational research and clinical correlations and classification.This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research".
KW - Autonomic seizures
KW - Autonomic status epilepticus
KW - Epilepsy
KW - Headache
KW - Ictal epileptic headache
KW - Migraine
KW - Migralepsy
KW - Tension-type headache
UR - http://www.scopus.com/inward/record.url?scp=84875233747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875233747&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2012.09.025
DO - 10.1016/j.yebeh.2012.09.025
M3 - Article
C2 - 23122969
AN - SCOPUS:84875233747
VL - 26
SP - 386
EP - 393
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 3
ER -