Headache and spontaneous low cerebrospinal fluid pressure syndrome

E. Mea, M. Savoiardo, L. Chiapparini, G. Casucci, V. Bonavita, G. Bussone, M. Leone

Research output: Contribution to journalArticlepeer-review


We examined 59 consecutive patients presenting between 1993 and 2006 at our centre diagnosed with headache associated with spontaneous intracranial hypotension syndrome (SIH). Thirty-six (61%) patients were women; the mean age was 47 years (range 20-68). Cerebral MRI with contrast confirmed SIH in all patients. Headache characteristics were obtained by direct semistructured interview; in a minority of cases information was completed retrospectively through a phone call. All SIH patients suffered from headache. Early recognition of SIH may avoid dangerous worsening due to delayed diagnosis. Orthostatic headache, the main symptom, suggests the diagnosis.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 2
Publication statusPublished - May 2007


  • Intracranial hypotension syndrome
  • Orthostatic headache
  • Postural headache
  • Spontaneous CSF hypovolaemia
  • Spontaneous intracranial hypotension

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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