Headache, seizures and repeated strokes in a young subject: A new case of MELAS-like syndrome?

G. Fabrizi, L. Manneschi, G. Marcacci, N. Volpi, P. Sabatelli, G. C. Guazzi, A. Federico

Research output: Contribution to journalArticle

Abstract

We report the case of a 21-year-old man affected by fluctuating stroke-like symptoms and computed-tomographic hypodensities, associated with seizures, headache, vomiting and a biochemically abnormal response of blood lactate and pyruvate after an oral glucose load. Muscle biopsy showed an increased number of subsarcolemmal mitochondria of increased size. Mitochondrial enzyme analysis was normal. The diagnosis of a MELAS-like mitochondrial disease even with minor muscle involvement is discussed.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalBrain Dysfunction
Volume1
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Fabrizi, G., Manneschi, L., Marcacci, G., Volpi, N., Sabatelli, P., Guazzi, G. C., & Federico, A. (1988). Headache, seizures and repeated strokes in a young subject: A new case of MELAS-like syndrome? Brain Dysfunction, 1(3), 161-168.