Headache therapy with neuronal stabilising drugs

Bruno Colombo, Dacia Libera, Pietro Oreste Annovazzi, Giancarlo Comi

Research output: Contribution to journalArticle

Abstract

Migraine is a frequent episodic condition that often requires prophylaxis treatment to reduce the severity, frequency and duration of attacks and to ameliorate disability. Migraine can be interpreted as a disorder of pain modulation, which involves the trigeminovascular system and central nervous system modulation of paincontrolling structures. Antiepileptic drugs (neuronal stabilising drugs, NSD) have been increasingly recommended for migraine prophylaxis because of several well conducted studies confirming their efficacy. Valproate, Topiramate and Gabapentin are indicated as useful drugs for migraine preventive therapy according to the results of randomised double-blind, placebo-controlled trials. Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy.

Original languageEnglish
JournalNeurological Sciences
Volume29
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2008

Fingerprint

Migraine Disorders
Headache
Pharmaceutical Preparations
Somatoform Disorders
Valproic Acid
Therapeutics
Anticonvulsants
Central Nervous System
Placebos

Keywords

  • Antiepileptic drugs
  • Headache
  • Prophylaxis
  • Therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Headache therapy with neuronal stabilising drugs. / Colombo, Bruno; Libera, Dacia; Annovazzi, Pietro Oreste; Comi, Giancarlo.

In: Neurological Sciences, Vol. 29, No. SUPPL. 1, 05.2008.

Research output: Contribution to journalArticle

Colombo, Bruno ; Libera, Dacia ; Annovazzi, Pietro Oreste ; Comi, Giancarlo. / Headache therapy with neuronal stabilising drugs. In: Neurological Sciences. 2008 ; Vol. 29, No. SUPPL. 1.
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