Abstract
Migraine is a frequent episodic condition that often requires prophylaxis treatment to reduce the severity, frequency and duration of attacks and to ameliorate disability. Migraine can be interpreted as a disorder of pain modulation, which involves the trigeminovascular system and central nervous system modulation of paincontrolling structures. Antiepileptic drugs (neuronal stabilising drugs, NSD) have been increasingly recommended for migraine prophylaxis because of several well conducted studies confirming their efficacy. Valproate, Topiramate and Gabapentin are indicated as useful drugs for migraine preventive therapy according to the results of randomised double-blind, placebo-controlled trials. Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy.
| Original language | English |
|---|---|
| Journal | Neurological Sciences |
| Volume | 29 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- Antiepileptic drugs
- Headache
- Prophylaxis
- Therapy
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Headache therapy with neuronal stabilising drugs. / Colombo, Bruno; Libera, Dacia; Annovazzi, Pietro Oreste; Comi, Giancarlo.
In: Neurological Sciences, Vol. 29, No. SUPPL. 1, 05.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Headache therapy with neuronal stabilising drugs
AU - Colombo, Bruno
AU - Libera, Dacia
AU - Annovazzi, Pietro Oreste
AU - Comi, Giancarlo
PY - 2008/5
Y1 - 2008/5
N2 - Migraine is a frequent episodic condition that often requires prophylaxis treatment to reduce the severity, frequency and duration of attacks and to ameliorate disability. Migraine can be interpreted as a disorder of pain modulation, which involves the trigeminovascular system and central nervous system modulation of paincontrolling structures. Antiepileptic drugs (neuronal stabilising drugs, NSD) have been increasingly recommended for migraine prophylaxis because of several well conducted studies confirming their efficacy. Valproate, Topiramate and Gabapentin are indicated as useful drugs for migraine preventive therapy according to the results of randomised double-blind, placebo-controlled trials. Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy.
AB - Migraine is a frequent episodic condition that often requires prophylaxis treatment to reduce the severity, frequency and duration of attacks and to ameliorate disability. Migraine can be interpreted as a disorder of pain modulation, which involves the trigeminovascular system and central nervous system modulation of paincontrolling structures. Antiepileptic drugs (neuronal stabilising drugs, NSD) have been increasingly recommended for migraine prophylaxis because of several well conducted studies confirming their efficacy. Valproate, Topiramate and Gabapentin are indicated as useful drugs for migraine preventive therapy according to the results of randomised double-blind, placebo-controlled trials. Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy.
KW - Antiepileptic drugs
KW - Headache
KW - Prophylaxis
KW - Therapy
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UR - http://www.scopus.com/inward/citedby.url?scp=45249111993&partnerID=8YFLogxK
U2 - 10.1007/s10072-008-0904-7
DO - 10.1007/s10072-008-0904-7
M3 - Article
C2 - 18545914
AN - SCOPUS:45249111993
VL - 29
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - SUPPL. 1
ER -