Headache with medication overuse: Treatment strategies and proposals of relapse prevention

Licia Grazzi, Frank Andrasik, Susanna Usai, Gennaro Bussone

Research output: Contribution to journalArticlepeer-review


The diagnosis of medication overuse headache (MOH) is clinically important, because patients rarely respond to preventive medications whilst overusing acute medications. Properly treating medication overuse and preventing relapse require recognition of the different factors that contribute to its development and perpetuation, including some behaviours and psychological elements that are important in sustaining the overuse of medication. This article reviews current clinical experiences of MOH patients treated with different approaches. Moreover, initial outcomes and long-term durability of treatments are discussed.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalNeurological Sciences
Issue number2
Publication statusPublished - Apr 2008


  • Behavioural therapies
  • Medication overuse headache
  • Pharmacological treatment
  • Withdrawal strategies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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