Abstract
We investigated the effect of nerve growth factor in goats affected by lameness, a condition that is associated with cutaneous ulcers, abscesses and granulomas. Lesions were treated daily with 1 μg of nerve growth factor (NGF), dissolved in 100 μl of sesame oil or with sesame oil only. Healthy controls were treated with sesame oil only for periods ranging from two to four weeks and behavioral, biochemical and histopathological conditions were evaluated. Topical application of NGF, but not sesame oil, promoted ulcer healing in all goats within two-three weeks of treatment. The effect of NGF was to re-establish in about 60 days normal locomotion and indirectly to improve feeding behavior and milk production. These findings suggest that NGF might be clinically useful for healing damaged skin in goats and confirm previous studies on human corneal ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 187-194 |
| Number of pages | 8 |
| Journal | Annali dell'Istituto Superiore di Sanita |
| Issue number | 2 |
| Publication status | Published - 2002 |
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Keywords
- Behavior
- Goat
- Lameness
- NGF
- Skin
- Ulcer
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Healing action of nerve growth factor on lameness in adult goats. / Costa, Nicola; Fiore, Marco; Aloe, Luigi.
In: Annali dell'Istituto Superiore di Sanita, No. 2, 2002, p. 187-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Healing action of nerve growth factor on lameness in adult goats
AU - Costa, Nicola
AU - Fiore, Marco
AU - Aloe, Luigi
PY - 2002
Y1 - 2002
N2 - We investigated the effect of nerve growth factor in goats affected by lameness, a condition that is associated with cutaneous ulcers, abscesses and granulomas. Lesions were treated daily with 1 μg of nerve growth factor (NGF), dissolved in 100 μl of sesame oil or with sesame oil only. Healthy controls were treated with sesame oil only for periods ranging from two to four weeks and behavioral, biochemical and histopathological conditions were evaluated. Topical application of NGF, but not sesame oil, promoted ulcer healing in all goats within two-three weeks of treatment. The effect of NGF was to re-establish in about 60 days normal locomotion and indirectly to improve feeding behavior and milk production. These findings suggest that NGF might be clinically useful for healing damaged skin in goats and confirm previous studies on human corneal ulcers.
AB - We investigated the effect of nerve growth factor in goats affected by lameness, a condition that is associated with cutaneous ulcers, abscesses and granulomas. Lesions were treated daily with 1 μg of nerve growth factor (NGF), dissolved in 100 μl of sesame oil or with sesame oil only. Healthy controls were treated with sesame oil only for periods ranging from two to four weeks and behavioral, biochemical and histopathological conditions were evaluated. Topical application of NGF, but not sesame oil, promoted ulcer healing in all goats within two-three weeks of treatment. The effect of NGF was to re-establish in about 60 days normal locomotion and indirectly to improve feeding behavior and milk production. These findings suggest that NGF might be clinically useful for healing damaged skin in goats and confirm previous studies on human corneal ulcers.
KW - Behavior
KW - Goat
KW - Lameness
KW - NGF
KW - Skin
KW - Ulcer
UR - http://www.scopus.com/inward/record.url?scp=0036025311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036025311&partnerID=8YFLogxK
M3 - Article
C2 - 12387143
AN - SCOPUS:0036025311
SP - 187
EP - 194
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
IS - 2
ER -