Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit: Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires

Maria Angela Cerruto, Carolina D'Elia, Salvatore Siracusano, Omar Saleh, Mauro Gacci, Giovanni Cacciamani, Vincenzo De Marco, Antonio Benito Porcaro, Matteo Balzarro, Mauro Niero, Cristina Lonardi, Massimo Iafrate, Pierfrancesco Bassi, Ciro Imbimbo, Marco Racioppi, Renato Talamini, Stefano Ciciliato, Sergio Serni, Marco Carini, Paolo VerzeWalter Artibani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To evaluate health-related quality of life (HR-QoL) outcomes in elderly patients with different type of urinary diversion (UD), ileal conduit (IC) and ileal orthotopic neobladder (IONB), after radical cystectomy (RC) for bladder cancer, by using validated self-reported cancer-specific instruments. Patients and Methods: We retrospectively reviewed 77 patients who received an IC or an IONB after RC. HR-QoL was assessed with specific and validated disease questionnaires, administered at last follow-up. Result: At univariate analysis, at a mean follow-up of 60.91 ± 5.63 months, IONB results were favourable with regard to the following HR-QoL aspects: nausea and vomiting (p = 0.045), pain (p = 0.049), appetite loss (p = 0.03), constipation (p = 0.000), financial impact (p = 0.012) and cognitive functioning (p = 0.000). This last functional aspect was significantly worse in female patients (p = 0.029). Emotional functioning was significantly better in patients without long-term complications (p = 0.016). At multivariate analysis, male gender and IONB were independent predictors of better cognitive functioning, while long-term complications negatively affected emotional functioning. Conclusions: Obtained results suggest that an IONB can also be suitable for elderly patients compared with an IC with few and selected advantages in favour of the former UD. Preoperative patient's selection, counselling, education and active participation in the decision-making process lead to a more suitable choice of treatment.

Original languageEnglish
Pages (from-to)346-352
Number of pages7
JournalUrologia Internationalis
Volume100
Issue number3
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Urinary Diversion
Cystectomy
Urinary Bladder Neoplasms
Cross-Sectional Studies
Quality of Life
Appetite
Constipation
Nausea
Patient Selection
Vomiting
Surveys and Questionnaires
Counseling
Decision Making
Multivariate Analysis
Education
Pain
Neoplasms

Keywords

  • Bladder cancer
  • Ileal conduit
  • Orthotopic neobladder
  • Quality of life
  • Radical cystectomy
  • Urinary diversions

ASJC Scopus subject areas

  • Urology

Cite this

Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit : Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires. / Cerruto, Maria Angela; D'Elia, Carolina; Siracusano, Salvatore; Saleh, Omar; Gacci, Mauro; Cacciamani, Giovanni; De Marco, Vincenzo; Porcaro, Antonio Benito; Balzarro, Matteo; Niero, Mauro; Lonardi, Cristina; Iafrate, Massimo; Bassi, Pierfrancesco; Imbimbo, Ciro; Racioppi, Marco; Talamini, Renato; Ciciliato, Stefano; Serni, Sergio; Carini, Marco; Verze, Paolo; Artibani, Walter.

In: Urologia Internationalis, Vol. 100, No. 3, 01.04.2018, p. 346-352.

Research output: Contribution to journalArticle

Cerruto, MA, D'Elia, C, Siracusano, S, Saleh, O, Gacci, M, Cacciamani, G, De Marco, V, Porcaro, AB, Balzarro, M, Niero, M, Lonardi, C, Iafrate, M, Bassi, P, Imbimbo, C, Racioppi, M, Talamini, R, Ciciliato, S, Serni, S, Carini, M, Verze, P & Artibani, W 2018, 'Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit: Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires', Urologia Internationalis, vol. 100, no. 3, pp. 346-352. https://doi.org/10.1159/000487644
Cerruto, Maria Angela ; D'Elia, Carolina ; Siracusano, Salvatore ; Saleh, Omar ; Gacci, Mauro ; Cacciamani, Giovanni ; De Marco, Vincenzo ; Porcaro, Antonio Benito ; Balzarro, Matteo ; Niero, Mauro ; Lonardi, Cristina ; Iafrate, Massimo ; Bassi, Pierfrancesco ; Imbimbo, Ciro ; Racioppi, Marco ; Talamini, Renato ; Ciciliato, Stefano ; Serni, Sergio ; Carini, Marco ; Verze, Paolo ; Artibani, Walter. / Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit : Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires. In: Urologia Internationalis. 2018 ; Vol. 100, No. 3. pp. 346-352.
@article{d1912f2fd357486aa4b7dfac3de81f60,
title = "Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit: Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires",
abstract = "Objective: To evaluate health-related quality of life (HR-QoL) outcomes in elderly patients with different type of urinary diversion (UD), ileal conduit (IC) and ileal orthotopic neobladder (IONB), after radical cystectomy (RC) for bladder cancer, by using validated self-reported cancer-specific instruments. Patients and Methods: We retrospectively reviewed 77 patients who received an IC or an IONB after RC. HR-QoL was assessed with specific and validated disease questionnaires, administered at last follow-up. Result: At univariate analysis, at a mean follow-up of 60.91 ± 5.63 months, IONB results were favourable with regard to the following HR-QoL aspects: nausea and vomiting (p = 0.045), pain (p = 0.049), appetite loss (p = 0.03), constipation (p = 0.000), financial impact (p = 0.012) and cognitive functioning (p = 0.000). This last functional aspect was significantly worse in female patients (p = 0.029). Emotional functioning was significantly better in patients without long-term complications (p = 0.016). At multivariate analysis, male gender and IONB were independent predictors of better cognitive functioning, while long-term complications negatively affected emotional functioning. Conclusions: Obtained results suggest that an IONB can also be suitable for elderly patients compared with an IC with few and selected advantages in favour of the former UD. Preoperative patient's selection, counselling, education and active participation in the decision-making process lead to a more suitable choice of treatment.",
keywords = "Bladder cancer, Ileal conduit, Orthotopic neobladder, Quality of life, Radical cystectomy, Urinary diversions",
author = "Cerruto, {Maria Angela} and Carolina D'Elia and Salvatore Siracusano and Omar Saleh and Mauro Gacci and Giovanni Cacciamani and {De Marco}, Vincenzo and Porcaro, {Antonio Benito} and Matteo Balzarro and Mauro Niero and Cristina Lonardi and Massimo Iafrate and Pierfrancesco Bassi and Ciro Imbimbo and Marco Racioppi and Renato Talamini and Stefano Ciciliato and Sergio Serni and Marco Carini and Paolo Verze and Walter Artibani",
year = "2018",
month = "4",
day = "1",
doi = "10.1159/000487644",
language = "English",
volume = "100",
pages = "346--352",
journal = "Urologia Internationalis",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Health-Related Quality of Life after Radical Cystectomy for Bladder Cancer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit

T2 - Results from a Multicentre Cross-Sectional Study Using Validated Questionnaires

AU - Cerruto, Maria Angela

AU - D'Elia, Carolina

AU - Siracusano, Salvatore

AU - Saleh, Omar

AU - Gacci, Mauro

AU - Cacciamani, Giovanni

AU - De Marco, Vincenzo

AU - Porcaro, Antonio Benito

AU - Balzarro, Matteo

AU - Niero, Mauro

AU - Lonardi, Cristina

AU - Iafrate, Massimo

AU - Bassi, Pierfrancesco

AU - Imbimbo, Ciro

AU - Racioppi, Marco

AU - Talamini, Renato

AU - Ciciliato, Stefano

AU - Serni, Sergio

AU - Carini, Marco

AU - Verze, Paolo

AU - Artibani, Walter

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objective: To evaluate health-related quality of life (HR-QoL) outcomes in elderly patients with different type of urinary diversion (UD), ileal conduit (IC) and ileal orthotopic neobladder (IONB), after radical cystectomy (RC) for bladder cancer, by using validated self-reported cancer-specific instruments. Patients and Methods: We retrospectively reviewed 77 patients who received an IC or an IONB after RC. HR-QoL was assessed with specific and validated disease questionnaires, administered at last follow-up. Result: At univariate analysis, at a mean follow-up of 60.91 ± 5.63 months, IONB results were favourable with regard to the following HR-QoL aspects: nausea and vomiting (p = 0.045), pain (p = 0.049), appetite loss (p = 0.03), constipation (p = 0.000), financial impact (p = 0.012) and cognitive functioning (p = 0.000). This last functional aspect was significantly worse in female patients (p = 0.029). Emotional functioning was significantly better in patients without long-term complications (p = 0.016). At multivariate analysis, male gender and IONB were independent predictors of better cognitive functioning, while long-term complications negatively affected emotional functioning. Conclusions: Obtained results suggest that an IONB can also be suitable for elderly patients compared with an IC with few and selected advantages in favour of the former UD. Preoperative patient's selection, counselling, education and active participation in the decision-making process lead to a more suitable choice of treatment.

AB - Objective: To evaluate health-related quality of life (HR-QoL) outcomes in elderly patients with different type of urinary diversion (UD), ileal conduit (IC) and ileal orthotopic neobladder (IONB), after radical cystectomy (RC) for bladder cancer, by using validated self-reported cancer-specific instruments. Patients and Methods: We retrospectively reviewed 77 patients who received an IC or an IONB after RC. HR-QoL was assessed with specific and validated disease questionnaires, administered at last follow-up. Result: At univariate analysis, at a mean follow-up of 60.91 ± 5.63 months, IONB results were favourable with regard to the following HR-QoL aspects: nausea and vomiting (p = 0.045), pain (p = 0.049), appetite loss (p = 0.03), constipation (p = 0.000), financial impact (p = 0.012) and cognitive functioning (p = 0.000). This last functional aspect was significantly worse in female patients (p = 0.029). Emotional functioning was significantly better in patients without long-term complications (p = 0.016). At multivariate analysis, male gender and IONB were independent predictors of better cognitive functioning, while long-term complications negatively affected emotional functioning. Conclusions: Obtained results suggest that an IONB can also be suitable for elderly patients compared with an IC with few and selected advantages in favour of the former UD. Preoperative patient's selection, counselling, education and active participation in the decision-making process lead to a more suitable choice of treatment.

KW - Bladder cancer

KW - Ileal conduit

KW - Orthotopic neobladder

KW - Quality of life

KW - Radical cystectomy

KW - Urinary diversions

UR - http://www.scopus.com/inward/record.url?scp=85043455215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043455215&partnerID=8YFLogxK

U2 - 10.1159/000487644

DO - 10.1159/000487644

M3 - Article

C2 - 29514144

AN - SCOPUS:85043455215

VL - 100

SP - 346

EP - 352

JO - Urologia Internationalis

JF - Urologia Internationalis

SN - 0042-1138

IS - 3

ER -