TY - JOUR
T1 - Health-related quality of life during treatment of elderly patients with hypertension
T2 - Results from Study on COgnition and Prognosis in the Elderly (SCOPE)
AU - Degl'Innocenti, Alessio
AU - Elmfeldt, D.
AU - Hofman, A.
AU - Lithell, H.
AU - Olofsson, B.
AU - Skoog, I.
AU - Trenkwalder, P.
AU - Zanchetti, A.
AU - Wiklund, I.
PY - 2004/4
Y1 - 2004/4
N2 - The Study on COgnition and Prognosis in the Elderly (SCOPE) was a multinational, randomised, double-blind study to assess the effects of candesartan 8-16 mg daily on cardiovascular events and cognitive function in elderly patients (aged 70-89 years) with mild to moderate hypertension. A total of 4937 patients were randomised to candesartan or placebo with other antihypertensive drugs (mostly diuretics, beta-blockers, and calcium antagonists) added as needed to control blood pressure. Only 16% of the patients in the control group received placebo alone. The mean follow-up was 3.7 years. The aim of this health-related quality of life (HRQL) substudy analysis was to investigate changes in HRQL during antihypertensive treatment, and possible differences in patients receiving candesartan-based or other antihypertensive treatment. Three validated HRQL instruments were used: the Psychological General Well-being (PGWB) Index, the Subjective Symptoms Assessment Profile (SSA-P), and the EuroQoL Health Utility Index (EuroQoL). The HRQL was generally good at baseline and well preserved during follow-up in the presence of substantial blood pressure reductions in both treatment groups. Several of the observed changes in score from baseline to last visit favoured candesartan-based compared to control treatment, particularly the changes in PGWB Anxiety (-0.5 vs -1.0, P = 0.01), PGWB Positive well-being (-0.8 vs -1.1, P = 0.04), SSA-P Cardiac symptoms (0.03 vs 0.10, P = 0.03), and EuroQoL Current health (-3.1 vs -5.3, P = 0.008). This favourable result may be related to the somewhat lower blood pressure associated with candesartan-based treatment. In conclusion, there should be no reason to withhold modern antihypertensive therapy in elderly patients due to concerns for a negative effect on HRQL.
AB - The Study on COgnition and Prognosis in the Elderly (SCOPE) was a multinational, randomised, double-blind study to assess the effects of candesartan 8-16 mg daily on cardiovascular events and cognitive function in elderly patients (aged 70-89 years) with mild to moderate hypertension. A total of 4937 patients were randomised to candesartan or placebo with other antihypertensive drugs (mostly diuretics, beta-blockers, and calcium antagonists) added as needed to control blood pressure. Only 16% of the patients in the control group received placebo alone. The mean follow-up was 3.7 years. The aim of this health-related quality of life (HRQL) substudy analysis was to investigate changes in HRQL during antihypertensive treatment, and possible differences in patients receiving candesartan-based or other antihypertensive treatment. Three validated HRQL instruments were used: the Psychological General Well-being (PGWB) Index, the Subjective Symptoms Assessment Profile (SSA-P), and the EuroQoL Health Utility Index (EuroQoL). The HRQL was generally good at baseline and well preserved during follow-up in the presence of substantial blood pressure reductions in both treatment groups. Several of the observed changes in score from baseline to last visit favoured candesartan-based compared to control treatment, particularly the changes in PGWB Anxiety (-0.5 vs -1.0, P = 0.01), PGWB Positive well-being (-0.8 vs -1.1, P = 0.04), SSA-P Cardiac symptoms (0.03 vs 0.10, P = 0.03), and EuroQoL Current health (-3.1 vs -5.3, P = 0.008). This favourable result may be related to the somewhat lower blood pressure associated with candesartan-based treatment. In conclusion, there should be no reason to withhold modern antihypertensive therapy in elderly patients due to concerns for a negative effect on HRQL.
KW - Candesartan
KW - Elderly
KW - Health-related quality of life
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=16544380286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16544380286&partnerID=8YFLogxK
U2 - 10.1038/sj.jhh.1001657
DO - 10.1038/sj.jhh.1001657
M3 - Article
C2 - 15037872
AN - SCOPUS:16544380286
VL - 18
SP - 239
EP - 245
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
IS - 4
ER -