Health-related quality of life in epilepsy: Findings obtained with a new Italian instrument

Ada Piazzini, Ettore Beghi, Katherine Turner, Monica Ferraroni

Research output: Contribution to journalArticlepeer-review


The aim of the present study was to evaluate the Epi-QoL, a new Italian-specific measure of health-related quality of life (HRQOL) for adults with epilepsy; the clinical variables that affected the HRQOL score were also assessed. The Epi-QoL is a 46-item self-administered questionnaire focusing on six domains: Physical Functioning, Cognitive Functioning, Emotional Well-Being, Social Functioning, Seizure Worry, and Medication Effects. Eight hundred fifteen patients recruited from 24 secondary and tertiary Italian centers for the care of epilepsy were assessed. The results supported the reliability and validity of the Epi-QoL as a measure of HRQOL. The variables that significantly affected HRQOL scores were: geographic area, gender, seizure frequency, prognostic categories, number of medications, comorbidity, presence of cognitive impairment, psychiatric disturbances, and disability. We believe that a new specific questionnaire for the evaluation of HRQOL in Italy can contribute much to the understanding of the influence of epilepsy on patients' lives.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalEpilepsy and Behavior
Issue number1
Publication statusPublished - Jul 2008


  • Adults
  • Epilepsy
  • Italian instrument
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology


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