Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: A European LeukemiaNet study

Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux, Argiris Symeonidis, Guillermo Sanz, Jaroslav Cermak, Moshe Mittelman, Eva Hellström-Lindberg, Saskia Langemeijer, Mette Skov Holm, Krzysztof Madry, Luca Malcovati, Aurelia Tatic, Ulrich Germing, Aleksandar Savic, Corine Van Marrewijk, Agnès Guerci-Bresler, Elisa LuñoJackie Droste, Fabio Efficace, Alex Smith, David Bowen, Theo De Witte

Research output: Contribution to journalArticle

Abstract

In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospecive data on HRQoL in lower-risk MDS remain rare. We assessed HRQOL by EQ-5D questionnaire at initial diagnosis in 1690 consecutive IPSS-Low/Int-1 MDS patients from the European LeukemiaNet Registry. Impairments were compared with age- and sex-matched EuroQol Group norms. A significant proportion of MDS patients reported moderate/severe problems in the dimensions pain/discomfort (49.5%), mobility (41.0%), anxiety/depression (37.9%), and usual activities (36.1%). Limitations in mobility, self-care, usual activities, pain/discomfort, and EQ-VAS were significantly more frequent in the old, in females, and in those with high co-morbidity burden, low haemoglobin levels, or red blood cells transfusion need (p < 0.001). In comparison to age- and sex-matched peers, the proportion of problems in usual activities and anxiety/depression was significantly higher in MDS patients (p < 0.001). MDS-related restrictions in the dimension mobility were most prominent in males, and in older people (p < 0.001); in anxiety/depression in females and in younger people (p < 0.001); and in EQ-VAS in women and in persons older than 75 years (p < 0.05). Patients newly diagnosed with IPSS lower-risk MDS experience a pronounced reduction in HRQoL and a clustering of restrictions in distinct dimensions of HRQoL as compared with reference populations.

Original languageEnglish
Pages (from-to)1380-1392
Number of pages13
JournalLeukemia
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

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Myelodysplastic Syndromes
Quality of Life
Population
Anxiety
Depression
Mobility Limitation
Pain
Erythrocyte Transfusion
Self Care
Cluster Analysis
Registries
Hemoglobins
Research Design
Morbidity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations : A European LeukemiaNet study. / Stauder, Reinhard; Yu, Ge; Koinig, Karin A.; Bagguley, Tim; Fenaux, Pierre; Symeonidis, Argiris; Sanz, Guillermo; Cermak, Jaroslav; Mittelman, Moshe; Hellström-Lindberg, Eva; Langemeijer, Saskia; Holm, Mette Skov; Madry, Krzysztof; Malcovati, Luca; Tatic, Aurelia; Germing, Ulrich; Savic, Aleksandar; Van Marrewijk, Corine; Guerci-Bresler, Agnès; Luño, Elisa; Droste, Jackie; Efficace, Fabio; Smith, Alex; Bowen, David; De Witte, Theo.

In: Leukemia, Vol. 32, No. 6, 01.06.2018, p. 1380-1392.

Research output: Contribution to journalArticle

Stauder, R, Yu, G, Koinig, KA, Bagguley, T, Fenaux, P, Symeonidis, A, Sanz, G, Cermak, J, Mittelman, M, Hellström-Lindberg, E, Langemeijer, S, Holm, MS, Madry, K, Malcovati, L, Tatic, A, Germing, U, Savic, A, Van Marrewijk, C, Guerci-Bresler, A, Luño, E, Droste, J, Efficace, F, Smith, A, Bowen, D & De Witte, T 2018, 'Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: A European LeukemiaNet study', Leukemia, vol. 32, no. 6, pp. 1380-1392. https://doi.org/10.1038/s41375-018-0089-x
Stauder, Reinhard ; Yu, Ge ; Koinig, Karin A. ; Bagguley, Tim ; Fenaux, Pierre ; Symeonidis, Argiris ; Sanz, Guillermo ; Cermak, Jaroslav ; Mittelman, Moshe ; Hellström-Lindberg, Eva ; Langemeijer, Saskia ; Holm, Mette Skov ; Madry, Krzysztof ; Malcovati, Luca ; Tatic, Aurelia ; Germing, Ulrich ; Savic, Aleksandar ; Van Marrewijk, Corine ; Guerci-Bresler, Agnès ; Luño, Elisa ; Droste, Jackie ; Efficace, Fabio ; Smith, Alex ; Bowen, David ; De Witte, Theo. / Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations : A European LeukemiaNet study. In: Leukemia. 2018 ; Vol. 32, No. 6. pp. 1380-1392.
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