TY - JOUR
T1 - Health-related quality of life in patients with myasthemia gravis and the relationship between patient-oriented assessment and conventional measurements
AU - Padua, L.
AU - Evoli, A.
AU - Aprile, I.
AU - Caliandro, P.
AU - Mazza, S.
AU - Padua, R.
AU - Tonali, P.
PY - 2002
Y1 - 2002
N2 - We assessed the health-related quality of life (HRQoL) of patients with myasthenia gravis (MG) and correlated it with the physician's measurements of MG. Patients with MG were evaluated by means of (1) self-administered questionnaires, (2) clinical examination, (3) Osserman classification, (4) anti-AChR antibody, and (5) neurophysiology. Relationships between patient-oriented assessment and conventional clinical-neurophysiological and serological findings were evaluated. A total of 46 patients, inpatients and outpatients (mean age 50.7 years, range 11-77 years, 17 males, 29 females) with MG diagnosis were studied. The Osserman scale and clinical examination findings were significantly related to the physical aspects of HRQoL. Mental aspects of the quality of life were not progressively involved as muscle deficit progressed, but even in a mild clinical picture, the mental aspects were deteriorated. Patient-oriented measures proved that the patient's quality of life was impaired especially with regard to physical aspects. Our data demonstrated that clinical measurements are related to the HRQoL. The results may be useful in developing a disease-specific patient-oriented tool.
AB - We assessed the health-related quality of life (HRQoL) of patients with myasthenia gravis (MG) and correlated it with the physician's measurements of MG. Patients with MG were evaluated by means of (1) self-administered questionnaires, (2) clinical examination, (3) Osserman classification, (4) anti-AChR antibody, and (5) neurophysiology. Relationships between patient-oriented assessment and conventional clinical-neurophysiological and serological findings were evaluated. A total of 46 patients, inpatients and outpatients (mean age 50.7 years, range 11-77 years, 17 males, 29 females) with MG diagnosis were studied. The Osserman scale and clinical examination findings were significantly related to the physical aspects of HRQoL. Mental aspects of the quality of life were not progressively involved as muscle deficit progressed, but even in a mild clinical picture, the mental aspects were deteriorated. Patient-oriented measures proved that the patient's quality of life was impaired especially with regard to physical aspects. Our data demonstrated that clinical measurements are related to the HRQoL. The results may be useful in developing a disease-specific patient-oriented tool.
KW - Myasthenia gravis
KW - Neuromuscular transmission
KW - Neurophysiology
KW - Patient-oriented
KW - Quality of life
KW - SF-36
UR - http://www.scopus.com/inward/record.url?scp=0036126222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036126222&partnerID=8YFLogxK
U2 - 10.1007/s100720100066
DO - 10.1007/s100720100066
M3 - Article
C2 - 11917973
AN - SCOPUS:0036126222
VL - 22
SP - 363
EP - 369
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 5
ER -