Health-related quality of life in patients with myasthemia gravis and the relationship between patient-oriented assessment and conventional measurements

L. Padua, A. Evoli, I. Aprile, P. Caliandro, S. Mazza, R. Padua, P. Tonali

Research output: Contribution to journalArticle

Abstract

We assessed the health-related quality of life (HRQoL) of patients with myasthenia gravis (MG) and correlated it with the physician's measurements of MG. Patients with MG were evaluated by means of (1) self-administered questionnaires, (2) clinical examination, (3) Osserman classification, (4) anti-AChR antibody, and (5) neurophysiology. Relationships between patient-oriented assessment and conventional clinical-neurophysiological and serological findings were evaluated. A total of 46 patients, inpatients and outpatients (mean age 50.7 years, range 11-77 years, 17 males, 29 females) with MG diagnosis were studied. The Osserman scale and clinical examination findings were significantly related to the physical aspects of HRQoL. Mental aspects of the quality of life were not progressively involved as muscle deficit progressed, but even in a mild clinical picture, the mental aspects were deteriorated. Patient-oriented measures proved that the patient's quality of life was impaired especially with regard to physical aspects. Our data demonstrated that clinical measurements are related to the HRQoL. The results may be useful in developing a disease-specific patient-oriented tool.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalNeurological Sciences
Volume22
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Myasthenia gravis
  • Neuromuscular transmission
  • Neurophysiology
  • Patient-oriented
  • Quality of life
  • SF-36

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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