Health-related quality of life in recurrent platinum-sensitive ovarian cancer-results from the calypso trial

M. Brundage, M. Gropp, F. Mefti, K. Mann, B. Lund, V. Gebski, G. Wolfram, N. Reed, S. Pignata, A. Ferrero, C. Brown, E. Eisenhauer, E. Pujade-Lauraine

Research output: Contribution to journalArticle

Abstract

Background: In the CALYPSO trial, carboplatin-pegylated liposomal doxorubicin (CD) demonstrated superior therapeutic index versus carboplatin-paclitaxel (CP) in patients with recurrent ovarian cancer. This paper reports the health-related quality of life (HRQoL) findings. Materials and methods: HRQoL was measured with the EORTC QoL-QC30 questionnaire and OV28 ovarian cancer module. Mean change scores from baseline in HRQoL subscales (five functional scales and global health status) in each arm and the proportion of patients improved or worsened were calculated every 3 months until 12 months. Results: Compliance was 90% at baseline and 76%, 64%, 57% at 3, 6, and 9 months, respectively. Baseline HRQoL showed already impaired global scores (mean 62/100) and considerable symptom burden (90% of patients reporting nonzero scores). Global QoL and abdominal symptom scores improved over time in both arms; at 6 months, 36% of patients met criteria for improved symptoms. Treatment with CD resulted in less peripheral neuropathy (9.8 versus 24.2), fewer other chemotherapy side-effects (9.5 versus 16.2), and less impact on body image (3.8 versus 10.4) versus CP (all P <0.02) at 6 months. Conclusions: These patient-reported outcomes confirm the overall lower toxicity of CD versus CP. The improved disease-related outcomes achieved with CD were not at the expense of QoL.

Original languageEnglish
Article numbermdr583
Pages (from-to)2020-2027
Number of pages8
JournalAnnals of Oncology
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Carboplatin
  • Paclitaxel
  • Pegylated liposomal doxorubicin
  • Platinum sensitive
  • Quality of life
  • Recurrent ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Brundage, M., Gropp, M., Mefti, F., Mann, K., Lund, B., Gebski, V., Wolfram, G., Reed, N., Pignata, S., Ferrero, A., Brown, C., Eisenhauer, E., & Pujade-Lauraine, E. (2012). Health-related quality of life in recurrent platinum-sensitive ovarian cancer-results from the calypso trial. Annals of Oncology, 23(8), 2020-2027. [mdr583]. https://doi.org/10.1093/annonc/mdr583