Health-related quality of life of long-term childhood cancer survivors: A population-based study from the Childhood Cancer Registry of Piedmont, Italy

Daniela Alessi, Elisa Dama, Ronald Barr, Maria Luisa Mosso, Milena Maule, Corrado Magnani, Guido Pastore, Franco Merletti

Research output: Contribution to journalArticlepeer-review

Abstract

Aim of the study: To determine the Health Related Quality of Life (HRQL) in a population-based cohort of long-term survivors of childhood cancer in Piedmont, northwestern Italy. Patients and methods: During 2003, a 15-item Health Utilities Index questionnaire was mailed to 1005 5-year survivors, identified from the population-based Childhood Cancer Registry of Piedmont, to derive scores for overall HRQL and for eight single attributes of health. Score differences were estimated as adjusted prevalence odds ratios. Results: A large majority of long-term survivors had moderately high scores for overall HRQL and for each of the single attributes. Males reported better overall HRQL and less morbidity with respect to dexterity, emotion and pain than females. Survivors diagnosed when they were 10-14 years of age had better overall HRQL and less morbidity with respect to emotion, cognition and pain than younger persons. Long-term survivors of central nervous system (CNS) tumours, retinoblastoma and bone tumours had greater impairment of overall HRQL, vision, ambulation, dexterity, cognition and pain than survivors of other forms of cancer. Conclusion: Many survivors of childhood cancer in Piedmont had fairly good overall HRQL. Greater probability of impaired HRQL was seen for females, survivors of CNS tumours, retinoblastoma and bone tumours, and persons diagnosed before 10 years of age.

Original languageEnglish
Pages (from-to)2545-2552
Number of pages8
JournalEuropean Journal of Cancer
Volume43
Issue number17
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Cancer registry
  • Childhood cancer survivors
  • Health-related quality of life
  • Population-based study

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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