Health resource utilization associated with skeletal-related events in patients with bone metastases

Results from a multinational retrospective - Prospective observational study - A cohort from 4 European countries

H. Hoefeler, I. Duran, G. Hechmati, C. Garzon Rodriguez, D. Lüftner, J. Ashcroft, A. Bahl, C. Atchison, R. Wei, E. Thomas, V. Lorusso

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Skeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options. Methods: Patients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1 or 2 were recruited. Information on health resource utilization (HRU; including number/duration of hospitalizations, outpatient visits, procedures), attributed by investigators to be associated with a SRE, was collected retrospectively for up to 97 days prior to enrollment and prospectively for up to 18-21 months. Results: A total of 631 patients contributing 1282 SREs, were enrolled across Germany, Italy, Spain and the United Kingdom. Approximately a third of all SREs required an inpatient stay. Mean duration of inpatient stay for patients with SREs requiring one ranged from 8.4 to 41.1 days across all countries and SRE types. Conclusion: All types of SREs are associated with substantial HRU burden. Preventing SREs by using the best therapeutic options available may help to reduce the burden to patients and healthcare systems.

Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalJournal of Bone Oncology
Volume3
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Health Resources
Observational Studies
Prospective Studies
Neoplasm Metastasis
Bone and Bones
Inpatients
Bone Neoplasms
Spontaneous Fractures
Spinal Cord Compression
Life Expectancy
Multiple Myeloma
Spain
Italy
Germany
Lung Neoplasms
Prostatic Neoplasms
Hospitalization
Outpatients
Economics
Research Personnel

Keywords

  • Advanced cancer
  • Bone metastases
  • Health resource utilization
  • Observational research
  • Skeletal-related event

ASJC Scopus subject areas

  • Oncology

Cite this

Health resource utilization associated with skeletal-related events in patients with bone metastases : Results from a multinational retrospective - Prospective observational study - A cohort from 4 European countries. / Hoefeler, H.; Duran, I.; Hechmati, G.; Rodriguez, C. Garzon; Lüftner, D.; Ashcroft, J.; Bahl, A.; Atchison, C.; Wei, R.; Thomas, E.; Lorusso, V.

In: Journal of Bone Oncology, Vol. 3, No. 2, 2014, p. 40-48.

Research output: Contribution to journalArticle

Hoefeler, H. ; Duran, I. ; Hechmati, G. ; Rodriguez, C. Garzon ; Lüftner, D. ; Ashcroft, J. ; Bahl, A. ; Atchison, C. ; Wei, R. ; Thomas, E. ; Lorusso, V. / Health resource utilization associated with skeletal-related events in patients with bone metastases : Results from a multinational retrospective - Prospective observational study - A cohort from 4 European countries. In: Journal of Bone Oncology. 2014 ; Vol. 3, No. 2. pp. 40-48.
@article{31ad4d98799a48d4a05b5dd6460b29d7,
title = "Health resource utilization associated with skeletal-related events in patients with bone metastases: Results from a multinational retrospective - Prospective observational study - A cohort from 4 European countries",
abstract = "Background: Skeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options. Methods: Patients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1 or 2 were recruited. Information on health resource utilization (HRU; including number/duration of hospitalizations, outpatient visits, procedures), attributed by investigators to be associated with a SRE, was collected retrospectively for up to 97 days prior to enrollment and prospectively for up to 18-21 months. Results: A total of 631 patients contributing 1282 SREs, were enrolled across Germany, Italy, Spain and the United Kingdom. Approximately a third of all SREs required an inpatient stay. Mean duration of inpatient stay for patients with SREs requiring one ranged from 8.4 to 41.1 days across all countries and SRE types. Conclusion: All types of SREs are associated with substantial HRU burden. Preventing SREs by using the best therapeutic options available may help to reduce the burden to patients and healthcare systems.",
keywords = "Advanced cancer, Bone metastases, Health resource utilization, Observational research, Skeletal-related event",
author = "H. Hoefeler and I. Duran and G. Hechmati and Rodriguez, {C. Garzon} and D. L{\"u}ftner and J. Ashcroft and A. Bahl and C. Atchison and R. Wei and E. Thomas and V. Lorusso",
year = "2014",
doi = "10.1016/j.jbo.2014.04.001",
language = "English",
volume = "3",
pages = "40--48",
journal = "Journal of Bone Oncology",
issn = "2212-1374",
publisher = "Elsevier GmbH",
number = "2",

}

TY - JOUR

T1 - Health resource utilization associated with skeletal-related events in patients with bone metastases

T2 - Results from a multinational retrospective - Prospective observational study - A cohort from 4 European countries

AU - Hoefeler, H.

AU - Duran, I.

AU - Hechmati, G.

AU - Rodriguez, C. Garzon

AU - Lüftner, D.

AU - Ashcroft, J.

AU - Bahl, A.

AU - Atchison, C.

AU - Wei, R.

AU - Thomas, E.

AU - Lorusso, V.

PY - 2014

Y1 - 2014

N2 - Background: Skeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options. Methods: Patients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1 or 2 were recruited. Information on health resource utilization (HRU; including number/duration of hospitalizations, outpatient visits, procedures), attributed by investigators to be associated with a SRE, was collected retrospectively for up to 97 days prior to enrollment and prospectively for up to 18-21 months. Results: A total of 631 patients contributing 1282 SREs, were enrolled across Germany, Italy, Spain and the United Kingdom. Approximately a third of all SREs required an inpatient stay. Mean duration of inpatient stay for patients with SREs requiring one ranged from 8.4 to 41.1 days across all countries and SRE types. Conclusion: All types of SREs are associated with substantial HRU burden. Preventing SREs by using the best therapeutic options available may help to reduce the burden to patients and healthcare systems.

AB - Background: Skeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options. Methods: Patients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1 or 2 were recruited. Information on health resource utilization (HRU; including number/duration of hospitalizations, outpatient visits, procedures), attributed by investigators to be associated with a SRE, was collected retrospectively for up to 97 days prior to enrollment and prospectively for up to 18-21 months. Results: A total of 631 patients contributing 1282 SREs, were enrolled across Germany, Italy, Spain and the United Kingdom. Approximately a third of all SREs required an inpatient stay. Mean duration of inpatient stay for patients with SREs requiring one ranged from 8.4 to 41.1 days across all countries and SRE types. Conclusion: All types of SREs are associated with substantial HRU burden. Preventing SREs by using the best therapeutic options available may help to reduce the burden to patients and healthcare systems.

KW - Advanced cancer

KW - Bone metastases

KW - Health resource utilization

KW - Observational research

KW - Skeletal-related event

UR - http://www.scopus.com/inward/record.url?scp=84926318472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926318472&partnerID=8YFLogxK

U2 - 10.1016/j.jbo.2014.04.001

DO - 10.1016/j.jbo.2014.04.001

M3 - Article

VL - 3

SP - 40

EP - 48

JO - Journal of Bone Oncology

JF - Journal of Bone Oncology

SN - 2212-1374

IS - 2

ER -