Abstract
The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods. Cochlear implant outcomes have been investigated. The prevalence of hearing loss in autoimmune and immune-mediated inner ear diseases, as referred by case reports or single-center statistics, is widely variable. More difficult is the evaluation of severe/profound SNHL, usually reported in relation to cochlear implantation. Though these patients represent ideal candidates for cochlear implantation, as they become deaf after years of hearing; the associated systemic disease, the specific damage on inner ear structures and the medication taken may influence the result of cochlear implantation. The main problem is the cochlear fibrosis or ossification that has been found to affect 50% of implanted ears in patients suffering from autoimmune and immune-mediated SNHL. Hence, in the presence of severe/profound SNHL earlier implantation may be indicated before post-inflammatory obliterative changes to the cochlea.
| Original language | English |
|---|---|
| Pages (from-to) | 644-652 |
| Number of pages | 9 |
| Journal | Autoimmunity Reviews |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2018 |
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Keywords
- Autoimmune inner ear disease
- Cochlear implant
- Hearing loss
- Immune-mediated inner ear disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Hearing loss in autoimmune disorders : Prevalence and therapeutic options. / Mancini, Patrizia; Atturo, Francesca; Di Mario, Alessia; Portanova, Ginevra; Ralli, Massimo; De Virgilio, Armando; de Vincentiis, Marco; Greco, Antonio.
In: Autoimmunity Reviews, Vol. 17, No. 7, 01.07.2018, p. 644-652.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hearing loss in autoimmune disorders
T2 - Prevalence and therapeutic options
AU - Mancini, Patrizia
AU - Atturo, Francesca
AU - Di Mario, Alessia
AU - Portanova, Ginevra
AU - Ralli, Massimo
AU - De Virgilio, Armando
AU - de Vincentiis, Marco
AU - Greco, Antonio
PY - 2018/7/1
Y1 - 2018/7/1
N2 - The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods. Cochlear implant outcomes have been investigated. The prevalence of hearing loss in autoimmune and immune-mediated inner ear diseases, as referred by case reports or single-center statistics, is widely variable. More difficult is the evaluation of severe/profound SNHL, usually reported in relation to cochlear implantation. Though these patients represent ideal candidates for cochlear implantation, as they become deaf after years of hearing; the associated systemic disease, the specific damage on inner ear structures and the medication taken may influence the result of cochlear implantation. The main problem is the cochlear fibrosis or ossification that has been found to affect 50% of implanted ears in patients suffering from autoimmune and immune-mediated SNHL. Hence, in the presence of severe/profound SNHL earlier implantation may be indicated before post-inflammatory obliterative changes to the cochlea.
AB - The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods. Cochlear implant outcomes have been investigated. The prevalence of hearing loss in autoimmune and immune-mediated inner ear diseases, as referred by case reports or single-center statistics, is widely variable. More difficult is the evaluation of severe/profound SNHL, usually reported in relation to cochlear implantation. Though these patients represent ideal candidates for cochlear implantation, as they become deaf after years of hearing; the associated systemic disease, the specific damage on inner ear structures and the medication taken may influence the result of cochlear implantation. The main problem is the cochlear fibrosis or ossification that has been found to affect 50% of implanted ears in patients suffering from autoimmune and immune-mediated SNHL. Hence, in the presence of severe/profound SNHL earlier implantation may be indicated before post-inflammatory obliterative changes to the cochlea.
KW - Autoimmune inner ear disease
KW - Cochlear implant
KW - Hearing loss
KW - Immune-mediated inner ear disease
UR - http://www.scopus.com/inward/record.url?scp=85047369123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047369123&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2018.01.014
DO - 10.1016/j.autrev.2018.01.014
M3 - Review article
C2 - 29729446
AN - SCOPUS:85047369123
VL - 17
SP - 644
EP - 652
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 7
ER -