Coinvolgimento cardiaco a riposo in pazienti affetti da sclerosi sistemica: Differenze fra forma diffusa e forma limitata

Translated title of the contribution: Heart involvement at rest in patients with systemic sclerosis: Differences between diffuse form and limited form

Alessia Faccini, Stefano Franchini, Maria Grazia Sabbadini, Paolo G. Camici

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Heart involvement confers a poor prognosis in patients affected by systemic sclerosis (SSc). Nevertheless, the prevalence of heart involvement in these patients is not fully known. In this study we analyzed the most frequent manifestations of heart involvement at rest in a cohort of patients with SSc, comparing their prevalence in patients with the limited form (lcSSc) and in patients with the diffuse form (dcSSc) of the disease, taking also into account the duration of the disease. Methods. We thoroughly evaluated with electrocardiographic and echocardiographic examinations 174 patients affected by SSc who were followed at our hospital between 2001 and 2011. They were divided according to the disease subtype (dcSSc vs lcSSc) and information about the disease duration was available for 121 of them (calculated from the onset of the Raynaud's phenomenon). Results. Patients with dcSSc had a greater prevalence of heart involvement at rest when evaluated within 5 and 10 years after the onset of the Raynaud's phenomenon (p=0.0051 within 5 years and p=0.035 within 10 years). Indeed, patients with dcSSc had a greater prevalence of atrioventricular conduction abnormalities within 20 years after the onset of the Raynaud's phenomenon (p=0.03 within 10 years and p=0.04 within 20 years) and a greater prevalence of valvular abnormalities within 5 years (p=0.04). In dcSSc there was a greater prevalence of rhythm disturbances in patients with a disease duration ≤20 or >20 years (p=0.04 within 20 years and p=0.04 after 20 years), but not in those with a disease duration ≤5 and ≤10 years. Left ventricular hypertrophy had a greater prevalence in dcSSc after 20 years of disease duration (p=0.02). Conclusions. Cardiac manifestation occurs earlier and more frequently in patients affected by dcSSc than in patients with lcSSc.

Translated title of the contributionHeart involvement at rest in patients with systemic sclerosis: Differences between diffuse form and limited form
Original languageItalian
Pages (from-to)44-50
Number of pages7
JournalGiornale Italiano di Cardiologia
Volume15
Issue number1
Publication statusPublished - Jan 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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