Heart 'omics' in AGEing (HOMAGE): Design, research objectives and characteristics of the common database

Lotte Jacobs, Lutgarde Thijs, Yu Jin, Faiez Zannad, Alexandre Mebazaa, Philippe Rouet, Florence Pinet, Christophe Bauters, Burkert Pieske, Andreas Tomaschitz, Mamas Mamas, Javier Diez, Kenneth McDonald, John G F Cleland, Hans Peter Brunner-La Rocca, Stephane Heymans, Roberto Latini, Serge Masson, Peter Sever, Christian DellesStuart Pocock, Timothy Collier, Tatiana Kuznetsova, Jan A. Staessen

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n = 7,124), patients with heart failure (n = 4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n = 31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.

Original languageEnglish
Pages (from-to)349-359
Number of pages11
JournalJournal of Biomedical Research
Volume28
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Heart failure
  • Heart failure with preserved ejection fraction
  • Heart failure with reduced ejection fraction
  • Left ventricle
  • Morbidity
  • Mortality
  • Population science

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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