Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients

Mario T. Kratz, Helmut Schumacher, Karen Sliwa, Roland Schmieder, Janine Pöss, Felix Mahfoud, Thomas Unger, Eva Lonn, Teo Koon, Guiseppe Mancia, Peter Sleight, Salim Yusuf, Michael Böhm

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims: Erectile dysfunction (ED) is associated with cardiovascular risk factors as elevated systolic blood pressure (SBP), resting high heart rate (HR), and endothelial dysfunction and predicts cardiovascular events. However, the interaction between high HR and SBP and the development of ED remains unclear. Methods and Results: We evaluated 1015 male patients enrolled in the ED substudy of ONTARGET and TRANSCEND, examining the influence of mean HR and mean SBP obtained over all study visits (mean 10.9-1.4 study visits) and their interaction with ED. In patients without pre-existing ED, new onset ED was detected in 29% of patients below, and 41% of patients above, the median of mean HR (OR 1.72, 95% CI 1.8-2.5, p=0.0047). In patients with pre-existing ED, high HR had no add-on effect. With or without pre-existing ED, high SBP had no influence after adjustment for covariates (OR 1.03, 95% CI 0.66-1.59, p=0.91). In a continuous model, it was shown that effects of high HR were prominent at low Koiner (Cologne) Evaluation of Erectile Function (KEED) score baseline values and in the presence of SBP above the median. Conclusions: In patients at risk for cardiovascular events, high HR is associated with ED, whereas the effect of high SBP was not significant. High resting HR might represent a cardiovascular risk indicator. Whether HR represents a potential treatment target to improve ED in high-risk individuals must be scrutinized in prospective trials.

Original languageEnglish
Pages (from-to)272-280
Number of pages9
JournalEuropean Journal of Preventive Cardiology
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Erectile Dysfunction
Heart Rate
Blood Pressure
Hypertension

Keywords

  • Endothelial dysfunction
  • endothelial function
  • heart rate
  • high cardiovascular risk

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

Cite this

Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients. / Kratz, Mario T.; Schumacher, Helmut; Sliwa, Karen; Schmieder, Roland; Pöss, Janine; Mahfoud, Felix; Unger, Thomas; Lonn, Eva; Koon, Teo; Mancia, Guiseppe; Sleight, Peter; Yusuf, Salim; Böhm, Michael.

In: European Journal of Preventive Cardiology, Vol. 21, No. 3, 03.2014, p. 272-280.

Research output: Contribution to journalArticle

Kratz, MT, Schumacher, H, Sliwa, K, Schmieder, R, Pöss, J, Mahfoud, F, Unger, T, Lonn, E, Koon, T, Mancia, G, Sleight, P, Yusuf, S & Böhm, M 2014, 'Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients', European Journal of Preventive Cardiology, vol. 21, no. 3, pp. 272-280. https://doi.org/10.1177/2047487313494835
Kratz, Mario T. ; Schumacher, Helmut ; Sliwa, Karen ; Schmieder, Roland ; Pöss, Janine ; Mahfoud, Felix ; Unger, Thomas ; Lonn, Eva ; Koon, Teo ; Mancia, Guiseppe ; Sleight, Peter ; Yusuf, Salim ; Böhm, Michael. / Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients. In: European Journal of Preventive Cardiology. 2014 ; Vol. 21, No. 3. pp. 272-280.
@article{8d10844aadd947c1ad7dd817bbe421c3,
title = "Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients",
abstract = "Aims: Erectile dysfunction (ED) is associated with cardiovascular risk factors as elevated systolic blood pressure (SBP), resting high heart rate (HR), and endothelial dysfunction and predicts cardiovascular events. However, the interaction between high HR and SBP and the development of ED remains unclear. Methods and Results: We evaluated 1015 male patients enrolled in the ED substudy of ONTARGET and TRANSCEND, examining the influence of mean HR and mean SBP obtained over all study visits (mean 10.9-1.4 study visits) and their interaction with ED. In patients without pre-existing ED, new onset ED was detected in 29{\%} of patients below, and 41{\%} of patients above, the median of mean HR (OR 1.72, 95{\%} CI 1.8-2.5, p=0.0047). In patients with pre-existing ED, high HR had no add-on effect. With or without pre-existing ED, high SBP had no influence after adjustment for covariates (OR 1.03, 95{\%} CI 0.66-1.59, p=0.91). In a continuous model, it was shown that effects of high HR were prominent at low Koiner (Cologne) Evaluation of Erectile Function (KEED) score baseline values and in the presence of SBP above the median. Conclusions: In patients at risk for cardiovascular events, high HR is associated with ED, whereas the effect of high SBP was not significant. High resting HR might represent a cardiovascular risk indicator. Whether HR represents a potential treatment target to improve ED in high-risk individuals must be scrutinized in prospective trials.",
keywords = "Endothelial dysfunction, endothelial function, heart rate, high cardiovascular risk",
author = "Kratz, {Mario T.} and Helmut Schumacher and Karen Sliwa and Roland Schmieder and Janine P{\"o}ss and Felix Mahfoud and Thomas Unger and Eva Lonn and Teo Koon and Guiseppe Mancia and Peter Sleight and Salim Yusuf and Michael B{\"o}hm",
year = "2014",
month = "3",
doi = "10.1177/2047487313494835",
language = "English",
volume = "21",
pages = "272--280",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients

AU - Kratz, Mario T.

AU - Schumacher, Helmut

AU - Sliwa, Karen

AU - Schmieder, Roland

AU - Pöss, Janine

AU - Mahfoud, Felix

AU - Unger, Thomas

AU - Lonn, Eva

AU - Koon, Teo

AU - Mancia, Guiseppe

AU - Sleight, Peter

AU - Yusuf, Salim

AU - Böhm, Michael

PY - 2014/3

Y1 - 2014/3

N2 - Aims: Erectile dysfunction (ED) is associated with cardiovascular risk factors as elevated systolic blood pressure (SBP), resting high heart rate (HR), and endothelial dysfunction and predicts cardiovascular events. However, the interaction between high HR and SBP and the development of ED remains unclear. Methods and Results: We evaluated 1015 male patients enrolled in the ED substudy of ONTARGET and TRANSCEND, examining the influence of mean HR and mean SBP obtained over all study visits (mean 10.9-1.4 study visits) and their interaction with ED. In patients without pre-existing ED, new onset ED was detected in 29% of patients below, and 41% of patients above, the median of mean HR (OR 1.72, 95% CI 1.8-2.5, p=0.0047). In patients with pre-existing ED, high HR had no add-on effect. With or without pre-existing ED, high SBP had no influence after adjustment for covariates (OR 1.03, 95% CI 0.66-1.59, p=0.91). In a continuous model, it was shown that effects of high HR were prominent at low Koiner (Cologne) Evaluation of Erectile Function (KEED) score baseline values and in the presence of SBP above the median. Conclusions: In patients at risk for cardiovascular events, high HR is associated with ED, whereas the effect of high SBP was not significant. High resting HR might represent a cardiovascular risk indicator. Whether HR represents a potential treatment target to improve ED in high-risk individuals must be scrutinized in prospective trials.

AB - Aims: Erectile dysfunction (ED) is associated with cardiovascular risk factors as elevated systolic blood pressure (SBP), resting high heart rate (HR), and endothelial dysfunction and predicts cardiovascular events. However, the interaction between high HR and SBP and the development of ED remains unclear. Methods and Results: We evaluated 1015 male patients enrolled in the ED substudy of ONTARGET and TRANSCEND, examining the influence of mean HR and mean SBP obtained over all study visits (mean 10.9-1.4 study visits) and their interaction with ED. In patients without pre-existing ED, new onset ED was detected in 29% of patients below, and 41% of patients above, the median of mean HR (OR 1.72, 95% CI 1.8-2.5, p=0.0047). In patients with pre-existing ED, high HR had no add-on effect. With or without pre-existing ED, high SBP had no influence after adjustment for covariates (OR 1.03, 95% CI 0.66-1.59, p=0.91). In a continuous model, it was shown that effects of high HR were prominent at low Koiner (Cologne) Evaluation of Erectile Function (KEED) score baseline values and in the presence of SBP above the median. Conclusions: In patients at risk for cardiovascular events, high HR is associated with ED, whereas the effect of high SBP was not significant. High resting HR might represent a cardiovascular risk indicator. Whether HR represents a potential treatment target to improve ED in high-risk individuals must be scrutinized in prospective trials.

KW - Endothelial dysfunction

KW - endothelial function

KW - heart rate

KW - high cardiovascular risk

UR - http://www.scopus.com/inward/record.url?scp=84896717404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896717404&partnerID=8YFLogxK

U2 - 10.1177/2047487313494835

DO - 10.1177/2047487313494835

M3 - Article

C2 - 23818288

AN - SCOPUS:84896717404

VL - 21

SP - 272

EP - 280

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 3

ER -