Abstract
Objective: During wakefulness, nociceptive thermal stimulation can trigger a rapid and transient rise in heart rate (HR). During sleep, HR variations are different across sleep stages; HR is more variable in stage 2 and in REM than in stages 3 and 4. The aim of this study was to assess the HR response to experimental thermal stimulation during different sleep stages. Methods: Eight young subjects free of sleep and pain problems, underwent a night of polysomnographic recording during which experimental thermal stimulations were applied. During all sleep stages (St), a series of cold, warm/control and heat pain stimulations were applied over the shoulder skin by means of a water-driven system. Variation of HR interval was measured for 6 s before and for 6 s during the thermal stimulation. Results: In comparison to control warm stimulation, experimental nociceptive thermal stimulation induced a significant rise in HR during sleep; HR increased by 7% in St 2, 5.4% in St 3&4, and by 4.3% in REM sleep. Conclusion: The brief increase in cardiac activity with experimental nociceptive stimulation suggests that during sleep, the autonomic-cardiac nervous system remains reactive to external sensory inputs and is part of the physiological response to preserve body safety and sleep integrity in the face of potentially harmful stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 532-535 |
| Number of pages | 4 |
| Journal | Clinical Neurophysiology |
| Volume | 112 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Autonomic response
- Heart rate
- Nociception
- Pain
- Quantitative sensory testing
- Sleep
- Thermal pain
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
- Neurology
- Sensory Systems
- Physiology (medical)
Cite this
Heart rate changes during sleep in response to experimental thermal (nociceptive) stimulations in healthy subjects. / Lavigne, Gilles J.; Zucconi, Marco; Castronovo, Vincenzia; Manzini, Christiane; Veglia, Fabrizio; Smirne, Salvatore; Ferini-Strambi, Luigi.
In: Clinical Neurophysiology, Vol. 112, No. 3, 2001, p. 532-535.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heart rate changes during sleep in response to experimental thermal (nociceptive) stimulations in healthy subjects
AU - Lavigne, Gilles J.
AU - Zucconi, Marco
AU - Castronovo, Vincenzia
AU - Manzini, Christiane
AU - Veglia, Fabrizio
AU - Smirne, Salvatore
AU - Ferini-Strambi, Luigi
PY - 2001
Y1 - 2001
N2 - Objective: During wakefulness, nociceptive thermal stimulation can trigger a rapid and transient rise in heart rate (HR). During sleep, HR variations are different across sleep stages; HR is more variable in stage 2 and in REM than in stages 3 and 4. The aim of this study was to assess the HR response to experimental thermal stimulation during different sleep stages. Methods: Eight young subjects free of sleep and pain problems, underwent a night of polysomnographic recording during which experimental thermal stimulations were applied. During all sleep stages (St), a series of cold, warm/control and heat pain stimulations were applied over the shoulder skin by means of a water-driven system. Variation of HR interval was measured for 6 s before and for 6 s during the thermal stimulation. Results: In comparison to control warm stimulation, experimental nociceptive thermal stimulation induced a significant rise in HR during sleep; HR increased by 7% in St 2, 5.4% in St 3&4, and by 4.3% in REM sleep. Conclusion: The brief increase in cardiac activity with experimental nociceptive stimulation suggests that during sleep, the autonomic-cardiac nervous system remains reactive to external sensory inputs and is part of the physiological response to preserve body safety and sleep integrity in the face of potentially harmful stimulation.
AB - Objective: During wakefulness, nociceptive thermal stimulation can trigger a rapid and transient rise in heart rate (HR). During sleep, HR variations are different across sleep stages; HR is more variable in stage 2 and in REM than in stages 3 and 4. The aim of this study was to assess the HR response to experimental thermal stimulation during different sleep stages. Methods: Eight young subjects free of sleep and pain problems, underwent a night of polysomnographic recording during which experimental thermal stimulations were applied. During all sleep stages (St), a series of cold, warm/control and heat pain stimulations were applied over the shoulder skin by means of a water-driven system. Variation of HR interval was measured for 6 s before and for 6 s during the thermal stimulation. Results: In comparison to control warm stimulation, experimental nociceptive thermal stimulation induced a significant rise in HR during sleep; HR increased by 7% in St 2, 5.4% in St 3&4, and by 4.3% in REM sleep. Conclusion: The brief increase in cardiac activity with experimental nociceptive stimulation suggests that during sleep, the autonomic-cardiac nervous system remains reactive to external sensory inputs and is part of the physiological response to preserve body safety and sleep integrity in the face of potentially harmful stimulation.
KW - Autonomic response
KW - Heart rate
KW - Nociception
KW - Pain
KW - Quantitative sensory testing
KW - Sleep
KW - Thermal pain
UR - http://www.scopus.com/inward/record.url?scp=0035107905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035107905&partnerID=8YFLogxK
U2 - 10.1016/S1388-2457(00)00558-7
DO - 10.1016/S1388-2457(00)00558-7
M3 - Article
C2 - 11222976
AN - SCOPUS:0035107905
VL - 112
SP - 532
EP - 535
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 3
ER -