Abstract
Background: Previous research has demonstrated the prognostic value of echocardiography with tissue Doppler imaging (TDI) in the heart failure (HF) population. Heart rate recovery (HRR) has also recently shown promise as a prognosticmarker. Hypothesis: We hypothesize echocardiography with TDI and HRR will be significantly correlated and both will provide prognostic information. Methods: A total of 243 subjects underwent echocardiography with TDI and maximal exercise testing to determine: (1) the ratio between mitral early (E) to mitral annular (E′) and E to mitral late (A) velocity; (2) left ventricular ejection fraction (LVEF); (3) left ventricular (LV) mass; (4) LV end-systolic volume (LVESV); and (5) HRR at 1 minute postexercise (HRR1). Results: HRR1 was significantly correlated with LVEF (r = 0.14, P = .03), LV mass (r = -0.30, P 1 was the strongest predictor of cardiacmortality (χ2: 55.5, P 2: 13.1, P 2: 11.2, P = .001), and LVESV (residualχ2: 5.9, P = .015) all added significant prognostic value and were retained in the regression while LVEF was removed (residual χ2: 0.008, P = .93). Conclusions: To our knowledge, this is the first investigation demonstrating an association between HRR and variables obtained from echocardiography with TDI in subjects with HF. The combination of both assessment techniques provides improved prognostic discrimination.
| Original language | English |
|---|---|
| Journal | Clinical Cardiology |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Heart rate recovery and tissue doppler echocardiography in heart failure. / Guazzi, Marco; Myers, Jonathan; Peberdy, Maryann; Bensimhon, Daniel; Chase, Paul; Pinkstaff, Sherry; Arena, Ross.
In: Clinical Cardiology, Vol. 33, No. 2, 02.2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heart rate recovery and tissue doppler echocardiography in heart failure
AU - Guazzi, Marco
AU - Myers, Jonathan
AU - Peberdy, Maryann
AU - Bensimhon, Daniel
AU - Chase, Paul
AU - Pinkstaff, Sherry
AU - Arena, Ross
PY - 2010/2
Y1 - 2010/2
N2 - Background: Previous research has demonstrated the prognostic value of echocardiography with tissue Doppler imaging (TDI) in the heart failure (HF) population. Heart rate recovery (HRR) has also recently shown promise as a prognosticmarker. Hypothesis: We hypothesize echocardiography with TDI and HRR will be significantly correlated and both will provide prognostic information. Methods: A total of 243 subjects underwent echocardiography with TDI and maximal exercise testing to determine: (1) the ratio between mitral early (E) to mitral annular (E′) and E to mitral late (A) velocity; (2) left ventricular ejection fraction (LVEF); (3) left ventricular (LV) mass; (4) LV end-systolic volume (LVESV); and (5) HRR at 1 minute postexercise (HRR1). Results: HRR1 was significantly correlated with LVEF (r = 0.14, P = .03), LV mass (r = -0.30, P 1 was the strongest predictor of cardiacmortality (χ2: 55.5, P 2: 13.1, P 2: 11.2, P = .001), and LVESV (residualχ2: 5.9, P = .015) all added significant prognostic value and were retained in the regression while LVEF was removed (residual χ2: 0.008, P = .93). Conclusions: To our knowledge, this is the first investigation demonstrating an association between HRR and variables obtained from echocardiography with TDI in subjects with HF. The combination of both assessment techniques provides improved prognostic discrimination.
AB - Background: Previous research has demonstrated the prognostic value of echocardiography with tissue Doppler imaging (TDI) in the heart failure (HF) population. Heart rate recovery (HRR) has also recently shown promise as a prognosticmarker. Hypothesis: We hypothesize echocardiography with TDI and HRR will be significantly correlated and both will provide prognostic information. Methods: A total of 243 subjects underwent echocardiography with TDI and maximal exercise testing to determine: (1) the ratio between mitral early (E) to mitral annular (E′) and E to mitral late (A) velocity; (2) left ventricular ejection fraction (LVEF); (3) left ventricular (LV) mass; (4) LV end-systolic volume (LVESV); and (5) HRR at 1 minute postexercise (HRR1). Results: HRR1 was significantly correlated with LVEF (r = 0.14, P = .03), LV mass (r = -0.30, P 1 was the strongest predictor of cardiacmortality (χ2: 55.5, P 2: 13.1, P 2: 11.2, P = .001), and LVESV (residualχ2: 5.9, P = .015) all added significant prognostic value and were retained in the regression while LVEF was removed (residual χ2: 0.008, P = .93). Conclusions: To our knowledge, this is the first investigation demonstrating an association between HRR and variables obtained from echocardiography with TDI in subjects with HF. The combination of both assessment techniques provides improved prognostic discrimination.
UR - http://www.scopus.com/inward/record.url?scp=77649260768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649260768&partnerID=8YFLogxK
U2 - 10.1002/clc.20548
DO - 10.1002/clc.20548
M3 - Article
C2 - 20043341
AN - SCOPUS:77649260768
VL - 33
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
IS - 2
ER -