Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The autonomic tone and reflexes after myocardial infarction substudy)

Azad Ghuran, Fiona Reid, Maria Teresa La Rovere, Georg Schmidt, J. Thomas Bigger, A. John Camm, Peter J. Schwartz, Marek Malik

Research output: Contribution to journalArticle

Abstract

A previous report on heart rate (HR) turbulence showed its value in postinfarction risk stratification. The present study determines the predictive value of HR turbulence in a low-risk population after acute myocardial infarction and provides insight into its pathophysiologic correlates. With use of the database of the The Autonomic Tone and Reflexes After Myocardial Infarction (ATRAMI) study, data were obtained from 1,212 survivors with a mean duration of follow-up of 20.3 months. The a priori end point was defined as the combination of fatal cardiac arrest and nonfatal cardiac arrest. HR turbulence characterized by turbulence onset (TO) and turbulence slope (TS) was calculated and correlated with baroreflex sensitivity (BRS) and the SD of the normal-to-normal RR intervals (SDNN). A composite index of cardiac autonomic function was assessed by combining HR turbulence (TO and TS), BRS, and SDNN. Both TO and TS correlated moderately but significantly with BRS and SDNN (r = 0.26 to 0.44, p

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalThe American Journal of Cardiology
Volume89
Issue number2
DOIs
Publication statusPublished - Jan 15 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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