Heart rate turbulence in chagas disease

Antonio Luiz P Ribeiro, Georg Schmidt, Marcos R. Sousa, Federico Lombardi, Murilo E D Gomes, Amanda A. Perez, Márcio V L Barros, Fernando S. Machado, Manoel Otávio Costa Rocha

Research output: Contribution to journalArticle

Abstract

Heart Rate Turbulence in Chagas Disease. Heart rate turbulence (HRT) quantifies the biphasic response of the sinus node to ventricular premature complexes (VPCs) and is a powerful electrocardiogram related risk predictor. VPCs are frequent in Chagas disease, a potentially lethal illness, and can hamper the analysis by conventional methods of autonomic heart control. The aim of the study was to examine HRT in patients with Chagas disease. Chagas disease patients and healthy controls (group O, n = 11) without other diseases were submitted to a standardized protocol, including electrocardiogram, echocardiography, and 24-hour Holter monitoring. Chagas disease patients were divided according to their left ventricular systolic function: normal (group 1, n = 103) and reduced ejection fraction (group 2, n = 23). Two HRT indices, turbulence onset (TO) and turbulence slope (TS), were calculated and compared among groups after adjustment for covariates like the prevalence of VPCs and the mean heart rate. Chagas disease patients had significantly altered TO (group 1: -0.0186, group 2: -0.0126) and TS (group 1: 10.844, group 2: 7.870) values in comparison with controls (TO - 0.0256, TS 19.829); P <0.001 for both comparisons. In conclusion, HRT data may be useful in the electrocardiographic analysis of autonomic heart control in Chagas disease. Its prognostic value remains to be determined.

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalPACE - Pacing and Clinical Electrophysiology
Volume26
Issue number1 II
Publication statusPublished - Jan 1 2003

Fingerprint

Chagas Disease
Heart Rate
Ventricular Premature Complexes
Electrocardiography
Ambulatory Electrocardiography
Sinoatrial Node
Left Ventricular Function
Echocardiography
Control Groups

Keywords

  • Chagas disease
  • Heart rate turbulence
  • Heart rate variability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ribeiro, A. L. P., Schmidt, G., Sousa, M. R., Lombardi, F., Gomes, M. E. D., Perez, A. A., ... Costa Rocha, M. O. (2003). Heart rate turbulence in chagas disease. PACE - Pacing and Clinical Electrophysiology, 26(1 II), 406-410.

Heart rate turbulence in chagas disease. / Ribeiro, Antonio Luiz P; Schmidt, Georg; Sousa, Marcos R.; Lombardi, Federico; Gomes, Murilo E D; Perez, Amanda A.; Barros, Márcio V L; Machado, Fernando S.; Costa Rocha, Manoel Otávio.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 26, No. 1 II, 01.01.2003, p. 406-410.

Research output: Contribution to journalArticle

Ribeiro, ALP, Schmidt, G, Sousa, MR, Lombardi, F, Gomes, MED, Perez, AA, Barros, MVL, Machado, FS & Costa Rocha, MO 2003, 'Heart rate turbulence in chagas disease', PACE - Pacing and Clinical Electrophysiology, vol. 26, no. 1 II, pp. 406-410.
Ribeiro ALP, Schmidt G, Sousa MR, Lombardi F, Gomes MED, Perez AA et al. Heart rate turbulence in chagas disease. PACE - Pacing and Clinical Electrophysiology. 2003 Jan 1;26(1 II):406-410.
Ribeiro, Antonio Luiz P ; Schmidt, Georg ; Sousa, Marcos R. ; Lombardi, Federico ; Gomes, Murilo E D ; Perez, Amanda A. ; Barros, Márcio V L ; Machado, Fernando S. ; Costa Rocha, Manoel Otávio. / Heart rate turbulence in chagas disease. In: PACE - Pacing and Clinical Electrophysiology. 2003 ; Vol. 26, No. 1 II. pp. 406-410.
@article{5f1c4cee9c5b4e459717fbebcc42687c,
title = "Heart rate turbulence in chagas disease",
abstract = "Heart Rate Turbulence in Chagas Disease. Heart rate turbulence (HRT) quantifies the biphasic response of the sinus node to ventricular premature complexes (VPCs) and is a powerful electrocardiogram related risk predictor. VPCs are frequent in Chagas disease, a potentially lethal illness, and can hamper the analysis by conventional methods of autonomic heart control. The aim of the study was to examine HRT in patients with Chagas disease. Chagas disease patients and healthy controls (group O, n = 11) without other diseases were submitted to a standardized protocol, including electrocardiogram, echocardiography, and 24-hour Holter monitoring. Chagas disease patients were divided according to their left ventricular systolic function: normal (group 1, n = 103) and reduced ejection fraction (group 2, n = 23). Two HRT indices, turbulence onset (TO) and turbulence slope (TS), were calculated and compared among groups after adjustment for covariates like the prevalence of VPCs and the mean heart rate. Chagas disease patients had significantly altered TO (group 1: -0.0186, group 2: -0.0126) and TS (group 1: 10.844, group 2: 7.870) values in comparison with controls (TO - 0.0256, TS 19.829); P <0.001 for both comparisons. In conclusion, HRT data may be useful in the electrocardiographic analysis of autonomic heart control in Chagas disease. Its prognostic value remains to be determined.",
keywords = "Chagas disease, Heart rate turbulence, Heart rate variability",
author = "Ribeiro, {Antonio Luiz P} and Georg Schmidt and Sousa, {Marcos R.} and Federico Lombardi and Gomes, {Murilo E D} and Perez, {Amanda A.} and Barros, {M{\'a}rcio V L} and Machado, {Fernando S.} and {Costa Rocha}, {Manoel Ot{\'a}vio}",
year = "2003",
month = "1",
day = "1",
language = "English",
volume = "26",
pages = "406--410",
journal = "PACE - Pacing and Clinical Electrophysiology",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "1 II",

}

TY - JOUR

T1 - Heart rate turbulence in chagas disease

AU - Ribeiro, Antonio Luiz P

AU - Schmidt, Georg

AU - Sousa, Marcos R.

AU - Lombardi, Federico

AU - Gomes, Murilo E D

AU - Perez, Amanda A.

AU - Barros, Márcio V L

AU - Machado, Fernando S.

AU - Costa Rocha, Manoel Otávio

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Heart Rate Turbulence in Chagas Disease. Heart rate turbulence (HRT) quantifies the biphasic response of the sinus node to ventricular premature complexes (VPCs) and is a powerful electrocardiogram related risk predictor. VPCs are frequent in Chagas disease, a potentially lethal illness, and can hamper the analysis by conventional methods of autonomic heart control. The aim of the study was to examine HRT in patients with Chagas disease. Chagas disease patients and healthy controls (group O, n = 11) without other diseases were submitted to a standardized protocol, including electrocardiogram, echocardiography, and 24-hour Holter monitoring. Chagas disease patients were divided according to their left ventricular systolic function: normal (group 1, n = 103) and reduced ejection fraction (group 2, n = 23). Two HRT indices, turbulence onset (TO) and turbulence slope (TS), were calculated and compared among groups after adjustment for covariates like the prevalence of VPCs and the mean heart rate. Chagas disease patients had significantly altered TO (group 1: -0.0186, group 2: -0.0126) and TS (group 1: 10.844, group 2: 7.870) values in comparison with controls (TO - 0.0256, TS 19.829); P <0.001 for both comparisons. In conclusion, HRT data may be useful in the electrocardiographic analysis of autonomic heart control in Chagas disease. Its prognostic value remains to be determined.

AB - Heart Rate Turbulence in Chagas Disease. Heart rate turbulence (HRT) quantifies the biphasic response of the sinus node to ventricular premature complexes (VPCs) and is a powerful electrocardiogram related risk predictor. VPCs are frequent in Chagas disease, a potentially lethal illness, and can hamper the analysis by conventional methods of autonomic heart control. The aim of the study was to examine HRT in patients with Chagas disease. Chagas disease patients and healthy controls (group O, n = 11) without other diseases were submitted to a standardized protocol, including electrocardiogram, echocardiography, and 24-hour Holter monitoring. Chagas disease patients were divided according to their left ventricular systolic function: normal (group 1, n = 103) and reduced ejection fraction (group 2, n = 23). Two HRT indices, turbulence onset (TO) and turbulence slope (TS), were calculated and compared among groups after adjustment for covariates like the prevalence of VPCs and the mean heart rate. Chagas disease patients had significantly altered TO (group 1: -0.0186, group 2: -0.0126) and TS (group 1: 10.844, group 2: 7.870) values in comparison with controls (TO - 0.0256, TS 19.829); P <0.001 for both comparisons. In conclusion, HRT data may be useful in the electrocardiographic analysis of autonomic heart control in Chagas disease. Its prognostic value remains to be determined.

KW - Chagas disease

KW - Heart rate turbulence

KW - Heart rate variability

UR - http://www.scopus.com/inward/record.url?scp=0348242855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0348242855&partnerID=8YFLogxK

M3 - Article

C2 - 12687855

AN - SCOPUS:0348242855

VL - 26

SP - 406

EP - 410

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 1 II

ER -