Heart rate variability and treatment outcome in major depression: A pilot study

Felipe A. Jain, Ian A. Cook, Andrew F. Leuchter, Aimee M. Hunter, Dmitry M. Davydov, Cristina Ottaviani, Molly Tartter, Caroline Crump, David Shapiro

Research output: Contribution to journalArticle

Abstract

Variations in heart rate variability (HRV) have been associated with major depressive disorder (MDD), but the relationship of baseline HRV to treatment outcome in MDD is unclear. We conducted a pilot study to examine associations between resting baseline HRV and MDD treatment outcome. We retrospectively tested several parameters of HRV in an MDD treatment study with escitalopram (ESC, N=26) to generate a model of how baseline HRV related to treatment outcome, and cross-validated the model in a separate trial of MDD treatment with Iyengar yoga (IY, N=16). Lower relative power of very low frequency (rVLF) HRV at baseline predicted improvement in depressive symptoms when adjusted for age and gender (R2>.43 and p

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalInternational Journal of Psychophysiology
Volume93
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Escitalopram
  • Heart rate variability
  • Major depressive disorder
  • Selective serotonin reuptake inhibitor
  • Very low frequency
  • Yoga

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)
  • Neuropsychology and Physiological Psychology
  • Medicine(all)

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  • Cite this

    Jain, F. A., Cook, I. A., Leuchter, A. F., Hunter, A. M., Davydov, D. M., Ottaviani, C., Tartter, M., Crump, C., & Shapiro, D. (2014). Heart rate variability and treatment outcome in major depression: A pilot study. International Journal of Psychophysiology, 93(2), 204-210. https://doi.org/10.1016/j.ijpsycho.2014.04.006