Heart rate variability arterial hypertension in young heart-transplanted recipients: Association progression of cardiac allograft vasculopathy?

Ugo Giordano, Guido Michielon, Francesca Calò Carducci, Lucilla Ravà, Sara Alfieri, Francesco Parisi, Giorgia Grutter

Research output: Contribution to journalArticle

Abstract

Hypertension and reduced HRV are frequent in heart-transplanted recipients. We studied 26 young recipients to investigate the relationship between BP and HRV during simultaneous 24-h monitoring. Presence of CAV was considered. All HRV measures were significantly lower than normal values. Significant correlations were found between mean daytime systolic BP and the rMSSD (p = 0.04), and mean daytime DBP and SDANN for all 5-min segments (p = 0.03) and between rMSSD and mean nighttime DBP (p = 0.03). Four patients were hypertensive during daytime, seven had a reduced nocturnal fall and two had a nocturnal rise in BP. Eight patients showed severe CAV grade (grade IV) on the Stanford scale, 13 moderate (grade III) and five mild (grade I-II). After a follow-up time of 30 months, four of the 13 patients (30%) with CAV grade III showed an increase to grade IV and all showed abnormalities of both HRV and ABPM patterns. The relationship between HRV abnormalities and arterial hypertension and CAV should be further explored.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalPediatric Transplantation
Volume17
Issue number5
DOIs
Publication statusPublished - Aug 2013

Keywords

  • heart rate variability
  • hypertension
  • pediatric heart transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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