Heart rate variability during specific sleep stages: A comparison of healthy subjects with patients after myocardial infarction

E. Vanoli, P. B. Adamson, [No Value] Ba-Lin, G. D. Pinna, R. Lazzara, W. C. Orr

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Heart rate variability (HRV) is typically higher during nighttime. This evidence supports the concept that overall, sleep is a condition during which vagal activity is dominant. Myocardial infarction (MI) results in a loss in the overall nocturnal HRV increase. However, the characteristics of HRV during specific sleep stages in normal subjects and, more importantly, after MI, are unknown. This study describes HRV during sleep stages in normal subjects and in patients with a recent MI. Methods and Results: HRV was measured from 5 minutes of continuous ECG recording in 8 subjects with no clinical evidence of coronary artery disease (age, 47±4 years) and in 8 patients with a recent MI (age, 51±2 years; NS versus control subjects) in the awake state, non-rapid eye movement (REM), and REM sleep. In normal subjects, the low- to high-frequency ratio (LF/HF) derived from power spectral analysis of HRV decreased significantly from the awake state to non-REM sleep (from 4±1.4 to 1.22±0.33, P

Original languageEnglish
Pages (from-to)1918-1922
Number of pages5
JournalCirculation
Volume91
Issue number7
Publication statusPublished - 1995

Keywords

  • heart rate
  • myocardial infarction
  • vagus nerve

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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