Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis

Marcio Clementino De Souza Santos, Marcio Clementino De Souza Santos, Luiz Carlos De Lima Silveira, Luiz Carlos De Lima Silveira, Luiz Carlos De Lima Silveira, Sílvia Cristina Garcia Moura-Tonello, Alberto Porta, Alberto Porta, Aparecida Maria Catai, Givago Da Silva Souza, Givago da Silva Souza

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

© 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective: To evaluate the heart rate variability (HRV) in patients with multibacillary leprosy using dynamic linear and nonlinear analysis. Material and methods: Twenty-one leprosy patients (mean age: 39.14 ±10.58 years) and 21 healthy subjects (mean age: 36.24 ± 12.64 years) completed the sample. Heart rate variability recording was performed by a Polar RS800 CX heart monitor during a period of 15 min in the supine position and 15 min in a sitting position. Analysis of HRV was performed by frequency domain from high frequency (HF) and low frequency (LF) spectral indexes in absolute and normalized units. The nonlinear analysis of HRV was calculated using symbolic analysis (0V%, 1V %, 2LV% and 2UV% indexes), Shannon entropy (SE) and normalized complexity index (NCI). Results: Linear analysis: both groups showed higher HF values (p < 0.05) and smaller LF values (p < 0.05) in supine than in sitting position. The leprosy patients showed higher LF values (p < 0.05) and smaller HF values (p < 0.05) compared to the controls on supine position. Symbolic analysis: leprosy patients had higher 0V% values (p < 0.05), smaller 2LV% values (p < 0.05) and 2UV % values compared to healthy subjects on both positions. The 1V % had higher values (p < 0.05) for leprosy patients than for controls in the sitting position. The control subjects had smaller 0V % values (p < 0.05), and higher 2UV % values (p < 0.05) in the supine position compared to the sitting position. Leprosy patients had higher 2UV index values (p < 0.05) in the supine position compared to the sitting position. In the complexity analysis, leprosy patients had smaller SE and NCI values (p < 0.05) than the control in the supine position. There was no difference between the SE and NCI values of leprosy and the control subjects in the sitting position. The control subjects had higher SE and NCI values (p < 0.05) in the supine position than in the sitting position. Conclusion: Leprosy patients had higher sympathetic modulation and smaller vagal modulation than controls, indicating less HRV and cardiac modulation with lower complexity. The control group displayed significant HRV differences in response to position changes while leprosy patients had fewer HRV differences after the same postural change. An analysis of HRV with linear and non-linear dynamics proved to be a reliable method and promising for the investigation of autonomic dysfunction in patients with multibacillary leprosy.
Original languageEnglish
JournalPLoS One
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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leprosy
Nonlinear analysis
Leprosy
heart rate
Heart Rate
Posture
Supine Position
Entropy
entropy
multibacillary leprosy
Multibacillary Leprosy
Modulation
Nonlinear Dynamics
Healthy Volunteers
Licensure
Systems Analysis
Reproduction
heart

Cite this

Santos, M. C. D. S., Santos, M. C. D. S., Silveira, L. C. D. L., Silveira, L. C. D. L., Silveira, L. C. D. L., Moura-Tonello, S. C. G., ... Souza, G. D. S. (2017). Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis. PLoS One, 12(7). https://doi.org/10.1371/journal.pone.0180677

Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis. / Santos, Marcio Clementino De Souza; Santos, Marcio Clementino De Souza; Silveira, Luiz Carlos De Lima; Silveira, Luiz Carlos De Lima; Silveira, Luiz Carlos De Lima; Moura-Tonello, Sílvia Cristina Garcia; Porta, Alberto; Porta, Alberto; Catai, Aparecida Maria; Souza, Givago Da Silva; Souza, Givago da Silva.

In: PLoS One, Vol. 12, No. 7, 01.07.2017.

Research output: Contribution to journalArticle

Santos, MCDS, Santos, MCDS, Silveira, LCDL, Silveira, LCDL, Silveira, LCDL, Moura-Tonello, SCG, Porta, A, Porta, A, Catai, AM, Souza, GDS & Souza, GDS 2017, 'Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis', PLoS One, vol. 12, no. 7. https://doi.org/10.1371/journal.pone.0180677
Santos MCDS, Santos MCDS, Silveira LCDL, Silveira LCDL, Silveira LCDL, Moura-Tonello SCG et al. Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis. PLoS One. 2017 Jul 1;12(7). https://doi.org/10.1371/journal.pone.0180677
Santos, Marcio Clementino De Souza ; Santos, Marcio Clementino De Souza ; Silveira, Luiz Carlos De Lima ; Silveira, Luiz Carlos De Lima ; Silveira, Luiz Carlos De Lima ; Moura-Tonello, Sílvia Cristina Garcia ; Porta, Alberto ; Porta, Alberto ; Catai, Aparecida Maria ; Souza, Givago Da Silva ; Souza, Givago da Silva. / Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis. In: PLoS One. 2017 ; Vol. 12, No. 7.
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title = "Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis",
abstract = "{\circledC} 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective: To evaluate the heart rate variability (HRV) in patients with multibacillary leprosy using dynamic linear and nonlinear analysis. Material and methods: Twenty-one leprosy patients (mean age: 39.14 ±10.58 years) and 21 healthy subjects (mean age: 36.24 ± 12.64 years) completed the sample. Heart rate variability recording was performed by a Polar RS800 CX heart monitor during a period of 15 min in the supine position and 15 min in a sitting position. Analysis of HRV was performed by frequency domain from high frequency (HF) and low frequency (LF) spectral indexes in absolute and normalized units. The nonlinear analysis of HRV was calculated using symbolic analysis (0V{\%}, 1V {\%}, 2LV{\%} and 2UV{\%} indexes), Shannon entropy (SE) and normalized complexity index (NCI). Results: Linear analysis: both groups showed higher HF values (p < 0.05) and smaller LF values (p < 0.05) in supine than in sitting position. The leprosy patients showed higher LF values (p < 0.05) and smaller HF values (p < 0.05) compared to the controls on supine position. Symbolic analysis: leprosy patients had higher 0V{\%} values (p < 0.05), smaller 2LV{\%} values (p < 0.05) and 2UV {\%} values compared to healthy subjects on both positions. The 1V {\%} had higher values (p < 0.05) for leprosy patients than for controls in the sitting position. The control subjects had smaller 0V {\%} values (p < 0.05), and higher 2UV {\%} values (p < 0.05) in the supine position compared to the sitting position. Leprosy patients had higher 2UV index values (p < 0.05) in the supine position compared to the sitting position. In the complexity analysis, leprosy patients had smaller SE and NCI values (p < 0.05) than the control in the supine position. There was no difference between the SE and NCI values of leprosy and the control subjects in the sitting position. The control subjects had higher SE and NCI values (p < 0.05) in the supine position than in the sitting position. Conclusion: Leprosy patients had higher sympathetic modulation and smaller vagal modulation than controls, indicating less HRV and cardiac modulation with lower complexity. The control group displayed significant HRV differences in response to position changes while leprosy patients had fewer HRV differences after the same postural change. An analysis of HRV with linear and non-linear dynamics proved to be a reliable method and promising for the investigation of autonomic dysfunction in patients with multibacillary leprosy.",
author = "Santos, {Marcio Clementino De Souza} and Santos, {Marcio Clementino De Souza} and Silveira, {Luiz Carlos De Lima} and Silveira, {Luiz Carlos De Lima} and Silveira, {Luiz Carlos De Lima} and Moura-Tonello, {S{\'i}lvia Cristina Garcia} and Alberto Porta and Alberto Porta and Catai, {Aparecida Maria} and Souza, {Givago Da Silva} and Souza, {Givago da Silva}",
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T1 - Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis

AU - Santos, Marcio Clementino De Souza

AU - Santos, Marcio Clementino De Souza

AU - Silveira, Luiz Carlos De Lima

AU - Silveira, Luiz Carlos De Lima

AU - Silveira, Luiz Carlos De Lima

AU - Moura-Tonello, Sílvia Cristina Garcia

AU - Porta, Alberto

AU - Porta, Alberto

AU - Catai, Aparecida Maria

AU - Souza, Givago Da Silva

AU - Souza, Givago da Silva

PY - 2017/7/1

Y1 - 2017/7/1

N2 - © 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective: To evaluate the heart rate variability (HRV) in patients with multibacillary leprosy using dynamic linear and nonlinear analysis. Material and methods: Twenty-one leprosy patients (mean age: 39.14 ±10.58 years) and 21 healthy subjects (mean age: 36.24 ± 12.64 years) completed the sample. Heart rate variability recording was performed by a Polar RS800 CX heart monitor during a period of 15 min in the supine position and 15 min in a sitting position. Analysis of HRV was performed by frequency domain from high frequency (HF) and low frequency (LF) spectral indexes in absolute and normalized units. The nonlinear analysis of HRV was calculated using symbolic analysis (0V%, 1V %, 2LV% and 2UV% indexes), Shannon entropy (SE) and normalized complexity index (NCI). Results: Linear analysis: both groups showed higher HF values (p < 0.05) and smaller LF values (p < 0.05) in supine than in sitting position. The leprosy patients showed higher LF values (p < 0.05) and smaller HF values (p < 0.05) compared to the controls on supine position. Symbolic analysis: leprosy patients had higher 0V% values (p < 0.05), smaller 2LV% values (p < 0.05) and 2UV % values compared to healthy subjects on both positions. The 1V % had higher values (p < 0.05) for leprosy patients than for controls in the sitting position. The control subjects had smaller 0V % values (p < 0.05), and higher 2UV % values (p < 0.05) in the supine position compared to the sitting position. Leprosy patients had higher 2UV index values (p < 0.05) in the supine position compared to the sitting position. In the complexity analysis, leprosy patients had smaller SE and NCI values (p < 0.05) than the control in the supine position. There was no difference between the SE and NCI values of leprosy and the control subjects in the sitting position. The control subjects had higher SE and NCI values (p < 0.05) in the supine position than in the sitting position. Conclusion: Leprosy patients had higher sympathetic modulation and smaller vagal modulation than controls, indicating less HRV and cardiac modulation with lower complexity. The control group displayed significant HRV differences in response to position changes while leprosy patients had fewer HRV differences after the same postural change. An analysis of HRV with linear and non-linear dynamics proved to be a reliable method and promising for the investigation of autonomic dysfunction in patients with multibacillary leprosy.

AB - © 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective: To evaluate the heart rate variability (HRV) in patients with multibacillary leprosy using dynamic linear and nonlinear analysis. Material and methods: Twenty-one leprosy patients (mean age: 39.14 ±10.58 years) and 21 healthy subjects (mean age: 36.24 ± 12.64 years) completed the sample. Heart rate variability recording was performed by a Polar RS800 CX heart monitor during a period of 15 min in the supine position and 15 min in a sitting position. Analysis of HRV was performed by frequency domain from high frequency (HF) and low frequency (LF) spectral indexes in absolute and normalized units. The nonlinear analysis of HRV was calculated using symbolic analysis (0V%, 1V %, 2LV% and 2UV% indexes), Shannon entropy (SE) and normalized complexity index (NCI). Results: Linear analysis: both groups showed higher HF values (p < 0.05) and smaller LF values (p < 0.05) in supine than in sitting position. The leprosy patients showed higher LF values (p < 0.05) and smaller HF values (p < 0.05) compared to the controls on supine position. Symbolic analysis: leprosy patients had higher 0V% values (p < 0.05), smaller 2LV% values (p < 0.05) and 2UV % values compared to healthy subjects on both positions. The 1V % had higher values (p < 0.05) for leprosy patients than for controls in the sitting position. The control subjects had smaller 0V % values (p < 0.05), and higher 2UV % values (p < 0.05) in the supine position compared to the sitting position. Leprosy patients had higher 2UV index values (p < 0.05) in the supine position compared to the sitting position. In the complexity analysis, leprosy patients had smaller SE and NCI values (p < 0.05) than the control in the supine position. There was no difference between the SE and NCI values of leprosy and the control subjects in the sitting position. The control subjects had higher SE and NCI values (p < 0.05) in the supine position than in the sitting position. Conclusion: Leprosy patients had higher sympathetic modulation and smaller vagal modulation than controls, indicating less HRV and cardiac modulation with lower complexity. The control group displayed significant HRV differences in response to position changes while leprosy patients had fewer HRV differences after the same postural change. An analysis of HRV with linear and non-linear dynamics proved to be a reliable method and promising for the investigation of autonomic dysfunction in patients with multibacillary leprosy.

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